Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine

The effects of the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine on DNA synthesis were studied using short time incubation (30-90 minutes). Both purine analogues at concentrations from 1-100 μM decreased the DNA synthesis of rat brain cortex in a dose-dependent manner and the m...

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Detalles Bibliográficos
Autores principales:	Yakisich, J.S., Sidén, A., Vargas, V.I., Eneroth, P., Cruz, M.
Formato:	JOUR
Materias:	cyclin dependent kinase cyclin dependent kinase inhibitor purine derivative animal cell animal tissue article brain cortex cell cycle DNA synthesis inhibition nonhuman priority journal rat time Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0006291X_v243_n3_p674_Yakisich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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