Mitoxantrone affects topoisomerase activities in human breast cancer cells

The effects of mitoxantrone, an antineoplastic DNA intercalator, on topoisomerase I and II were studied in two human breast cancer cell lines. A large increase of topoisomerase I activity was found when cells were exposed to various doses of mitoxantrone. Maximal effect was achieved with 20 and 40 n...

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Detalles Bibliográficos
Autores principales: Crespi, M.D., Ivanier, S.E., Genovese, J., Baldi, A.
Formato: JOUR
Materias:
dactinomycin
dna
dna topoisomerase
mitoxantrone
puromycin
breast
breast cancer
cancer chemotherapy
drug cytotoxicity
enzyme inhibition
human
human cell
intoxication
priority journal
therapy
Anthraquinones
Breast Neoplasms
Cell Line
Comparative Study
Dactinomycin
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Doxorubicin
Enzyme Induction
Human
Kinetics
Mitoxantrone
Puromycin
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0006291X_v136_n2_p521_Crespi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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