Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
The secretion of interleukin 2 (IL-2) is a key event in T cell activation. IL-2 allows T cells to enter into the S phase of the cell cycle and divide. After the activation phase takes place, T lymphocytes proliferate and differentiate to generate effector T cells. Thereby, T helper (Th) precursor ce...
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todo:paper_0004069X_v51_n6_p351_Liberman2023-10-03T13:57:10Z Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation Liberman, A.C. Refojo, D. Arzt, E. GATA-3 IL-2 T cell activation T cell differentiation T-bet TCR binding protein CD28 antigen cytokine gamma interferon glucocorticoid immunoglobulin enhancer binding protein interleukin 12 interleukin 2 interleukin 4 interleukin 5 leucine zipper protein messenger RNA STAT protein T lymphocyte receptor transcription factor transcription factor GATA 3 transcription factor NFAT cell cycle cell division cellular immunity clone effector cell gene expression humoral immunity lymphocyte differentiation lymphocyte proliferation nonhuman precursor review signal transduction T lymphocyte activation Th1 cell Th2 cell transcription regulation Animals Cell Differentiation Gene Expression Regulation Humans Interleukin-2 Lymphocyte Activation Signal Transduction T-Lymphocyte Subsets Th1 Cells Th2 Cells Transcription Factors The secretion of interleukin 2 (IL-2) is a key event in T cell activation. IL-2 allows T cells to enter into the S phase of the cell cycle and divide. After the activation phase takes place, T lymphocytes proliferate and differentiate to generate effector T cells. Thereby, T helper (Th) precursor cells, which are functionally immature, may become Th1 or Th2 effector cells. These subsets are responsible for cell-mediated immunity and humoral responses, respectively. Both T cell activation and Th differentiation are processes that depend on changes in the pattern of gene expression. The expression and changes in the genes responsible for these events are regulated by transcription factors. This review will focus on both the transcription factors involved in the control of IL-2 as well as those that are key to T helper differentiation. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0004069X_v51_n6_p351_Liberman |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
GATA-3 IL-2 T cell activation T cell differentiation T-bet TCR binding protein CD28 antigen cytokine gamma interferon glucocorticoid immunoglobulin enhancer binding protein interleukin 12 interleukin 2 interleukin 4 interleukin 5 leucine zipper protein messenger RNA STAT protein T lymphocyte receptor transcription factor transcription factor GATA 3 transcription factor NFAT cell cycle cell division cellular immunity clone effector cell gene expression humoral immunity lymphocyte differentiation lymphocyte proliferation nonhuman precursor review signal transduction T lymphocyte activation Th1 cell Th2 cell transcription regulation Animals Cell Differentiation Gene Expression Regulation Humans Interleukin-2 Lymphocyte Activation Signal Transduction T-Lymphocyte Subsets Th1 Cells Th2 Cells Transcription Factors |
| spellingShingle |
GATA-3 IL-2 T cell activation T cell differentiation T-bet TCR binding protein CD28 antigen cytokine gamma interferon glucocorticoid immunoglobulin enhancer binding protein interleukin 12 interleukin 2 interleukin 4 interleukin 5 leucine zipper protein messenger RNA STAT protein T lymphocyte receptor transcription factor transcription factor GATA 3 transcription factor NFAT cell cycle cell division cellular immunity clone effector cell gene expression humoral immunity lymphocyte differentiation lymphocyte proliferation nonhuman precursor review signal transduction T lymphocyte activation Th1 cell Th2 cell transcription regulation Animals Cell Differentiation Gene Expression Regulation Humans Interleukin-2 Lymphocyte Activation Signal Transduction T-Lymphocyte Subsets Th1 Cells Th2 Cells Transcription Factors Liberman, A.C. Refojo, D. Arzt, E. Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| topic_facet |
GATA-3 IL-2 T cell activation T cell differentiation T-bet TCR binding protein CD28 antigen cytokine gamma interferon glucocorticoid immunoglobulin enhancer binding protein interleukin 12 interleukin 2 interleukin 4 interleukin 5 leucine zipper protein messenger RNA STAT protein T lymphocyte receptor transcription factor transcription factor GATA 3 transcription factor NFAT cell cycle cell division cellular immunity clone effector cell gene expression humoral immunity lymphocyte differentiation lymphocyte proliferation nonhuman precursor review signal transduction T lymphocyte activation Th1 cell Th2 cell transcription regulation Animals Cell Differentiation Gene Expression Regulation Humans Interleukin-2 Lymphocyte Activation Signal Transduction T-Lymphocyte Subsets Th1 Cells Th2 Cells Transcription Factors |
| description |
The secretion of interleukin 2 (IL-2) is a key event in T cell activation. IL-2 allows T cells to enter into the S phase of the cell cycle and divide. After the activation phase takes place, T lymphocytes proliferate and differentiate to generate effector T cells. Thereby, T helper (Th) precursor cells, which are functionally immature, may become Th1 or Th2 effector cells. These subsets are responsible for cell-mediated immunity and humoral responses, respectively. Both T cell activation and Th differentiation are processes that depend on changes in the pattern of gene expression. The expression and changes in the genes responsible for these events are regulated by transcription factors. This review will focus on both the transcription factors involved in the control of IL-2 as well as those that are key to T helper differentiation. |
| format |
JOUR |
| author |
Liberman, A.C. Refojo, D. Arzt, E. |
| author_facet |
Liberman, A.C. Refojo, D. Arzt, E. |
| author_sort |
Liberman, A.C. |
| title |
Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| title_short |
Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| title_full |
Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| title_fullStr |
Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| title_full_unstemmed |
Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation |
| title_sort |
cytokine signaling/transcription factor cross-talk in t cell activation and th1-th2 differentiation |
| url |
http://hdl.handle.net/20.500.12110/paper_0004069X_v51_n6_p351_Liberman |
| work_keys_str_mv |
AT libermanac cytokinesignalingtranscriptionfactorcrosstalkintcellactivationandth1th2differentiation AT refojod cytokinesignalingtranscriptionfactorcrosstalkintcellactivationandth1th2differentiation AT arzte cytokinesignalingtranscriptionfactorcrosstalkintcellactivationandth1th2differentiation |
| _version_ |
1807315314803736576 |