Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway

Leptin (Ob), the peripheral signal produced by the adipocyte to regulate energy metabolism, can also be produced by placenta, where it may work as an autocrine hormone. Recently, we have demonstrated that leptin promotes proliferation and survival of trophoblastic cells. In the present work we aimed...

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Detalles Bibliográficos
Autores principales: Pérez-Pérez, A., Maymó, J., Dueñas, J.L., Goberna, R., Calvo, J.C., Varone, C., Sánchez-Margalet, V.
Formato: JOUR
Materias:
Apoptosis
Leptin
Leptin receptor
Placenta
Signal transduction
caspase 3
Janus kinase
Janus kinase 2
leptin
leptin receptor
lipocortin 5
mitogen activated protein kinase
propidium iodide
protein kinase B
STAT protein
STAT3 protein
apoptosis
article
cell activation
cell line
choriocarcinoma
flow cytometry
human
human cell
phosphorylation
placenta
prevention and control
priority journal
protein phosphorylation
trophoblast
Cell Line
Dose-Response Relationship, Drug
Enzyme Activation
Humans
MAP Kinase Signaling System
Trophoblasts
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00039861_v477_n2_p390_PerezPerez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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