Drug treatment of hypertension in the elderly: A meta-analysis

Purpose: A meta-analysis of the effect of antihypertensive drug treatment on mortality and morbidity in elderly patients. Data sources: A literature search of published articles from January 1980 to February 1992. Study selection: Randomized controlled trials of drug treatment of hypertension with e...

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Detalles Bibliográficos
Autores principales: Insua, J.T., Sacks, H.S., Lau, T.-S., Lau, J., Reitman, D., Pagano, D., Chalmers, T.C.
Formato: JOUR
Materias:
amiloride
antihypertensive agent
atenolol
bendroflumethiazide
chlorothiazide
chlortalidone
clonidine
hydralazine
hydrochlorothiazide
methyldopa
nifedipine
pindolol
propranolol
reserpine
spironolactone
triamterene
adult
aged
aging
clinical trial
controlled clinical trial
controlled study
female
human
hypertension
major clinical study
male
meta analysis
multicenter study
priority journal
randomized controlled trial
review
Aged
Aged, 80 and over
Cerebrovascular Disorders
Coronary Disease
Female
Humans
Hypertension
Male
Middle Aged
Odds Ratio
Severity of Illness Index
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00034819_v121_n5_p355_Insua
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Purpose: A meta-analysis of the effect of antihypertensive drug treatment on mortality and morbidity in elderly patients. Data sources: A literature search of published articles from January 1980 to February 1992. Study selection: Randomized controlled trials of drug treatment of hypertension with end points for elderly patients reported separately. Data extraction: Mortality or morbidity end points or both in patients older than 59 years were pooled by determination of typical odds ratio. A meta-regression was used to study heterogeneity. Results: Nine major trials with 15559 patients older than 59 years were identified. Death rates in the control group varied between 2.7% and 77.2%; stroke and coronary mortality increased with the severity-of-illness rank (P < 0.001). Overall, treated patients had an approximately 12% reduction in all-cause mortality (odds ratio, 0.88; 95% CI, 0.80 to 0.97; 953 events compared with 1069 events, P = 0.009). There was a 36% reduction in stroke mortality (odds ratio, 0.64; CI, 0.49 to 0.82; 94 events compared with 149 events, P < 0.001) and a 25% reduction in coronary heart disease mortality (odds ratio, 0.75; CI, 0.64 to 0.88; 263 events compared with 350 events, P < 0.001). Coronary morbidity was reduced 15% (odds ratio, 0.85; CI, 0.73 to 0.99; 325 events compared with 379 events, P = 0.036), and stroke morbidity was reduced 35% (odds ratio, 0.65; CI, 0.55 to 0.76; 247 events compared with 382 events, P < 0.001). Conclusion: Overall, treatment of hypertension in elderly patients produces a significant benefit in total mortality and cardiovascular morbidity and mortality. However, this benefit may be reduced in the oldest age groups.

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