Case report: Molecular identification of Trypanosoma cruzi i tropism for central nervous system in chagas reactivation due to AIDS

Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, t...

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Detalles Bibliográficos
Autores principales: Burgos, J.M., Begher, S., Silva, H.M.V., Bisio, M., Duffy, T., Levin, M.J., Macedo, A.M., Schijman, A.G.
Formato: JOUR
Materias:
parasite antibody
cytochrome c oxidase
microsatellite DNA
protozoal DNA
acquired immune deficiency syndrome
adult
allele
article
blood sampling
case report
central nervous system
cerebrospinal fluid
Chagas disease
genetic polymorphism
haplotype
human
male
microsatellite marker
mitochondrion
nonhuman
parasite identification
Trypanosoma cruzi
AIDS related complex
animal
blood
Bolivia
central nervous system infection
fatality
genetics
isolation and purification
parasitology
physiology
plant growth
recurrent disease
restriction fragment length polymorphism
Acquired Immunodeficiency Syndrome
Adult
AIDS-Related Opportunistic Infections
Animals
Central Nervous System
Central Nervous System Protozoal Infections
Chagas Disease
DNA, Protozoan
Electron Transport Complex IV
Fatal Outcome
Humans
Male
Microsatellite Repeats
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Recurrence
Tropism
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00029637_v78_n2_p294_Burgos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Trypanosoma cruzi lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient's blood was infected by a mixture of T. cruzi I and T. cruzi IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal T. cruzi I population. Our findings do not corroborate the original assumption of innocuity for T. cruzi I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.

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