Structured and Unstructured Binding of an Intrinsically Disordered Protein as Revealed by Atomistic Simulations

Intrinsically disordered proteins (IDPs) are a set of proteins that lack a definite secondary structure in solution. IDPs can acquire tertiary structure when bound to their partners; therefore, the recognition process must also involve protein folding. The nature of the transition state (TS), struct...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ithuralde, R.E., Roitberg, A.E., Turjanski, A.G.
Formato: JOUR
Materias:
Bins
Free energy
Molecular dynamics
Proteins
Technology transfer
Atomistic molecular dynamics
Atomistic simulations
CREB binding proteins
Experimental techniques
Free energy surface
Intrinsically disordered proteins
Molecular simulations
Secondary structures
Binding energy
amino acid
cyclic AMP responsive element binding protein binding protein
intrinsically disordered protein
protein c Myb
tryptophan
Article
binding kinetics
hinge region
hydrophobicity
mean residence time
molecular dynamics
nuclear magnetic resonance
protein binding
protein conformation
protein folding
protein protein interaction
protein secondary structure
surface property
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v138_n28_p8742_Ithuralde
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares