Molecular basis for the electric field modulation of cytochrome c structure and function

Cytochrome c (Cyt) is a small soluble heme protein with a hexacoordinated heme and functions as an electron shuttle in the mitochondria and in early events of apoptosis when released to the cytoplasm. Using molecular dynamics simulations, we show here that biologically relevant electric fields induc...

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Detalles Bibliográficos
Autores principales: De Biase, P.M., Paggi, D.A., Doctorovich, F., Hildebrandt, P., Estrin, D.A., Murgida, D.H., Marti, M.A.
Formato: JOUR
Materias:
Apoptosis
Axial ligand
Conformational change
Conformational transitions
Cytochrome C
Electric field modulation
Electron shuttle
Electron-transfer reactions
Heme iron
Heme proteins
High spins
Molecular basis
Molecular dynamics simulations
Pentacoordinated
Peroxidase activities
Protein segments
Reduction potential
Respiratory chains
Structural distortions
Structural effect
Cell death
Electric fields
Mitochondria
Molecular dynamics
Porphyrins
Reaction kinetics
Redox reactions
Hemoglobin
cytochrome c
heme
hemoprotein
iron
peroxidase
article
conformational transition
electric field
electron transport
enzyme structure
molecular dynamics
oxidation reduction reaction
protein function
simulation
Cytochromes c
Heme
Ligands
Molecular Dynamics Simulation
Oxidation-Reduction
Peroxidases
Protein Conformation
Static Electricity
Thermodynamics
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v131_n44_p16248_DeBiase
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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