Transnitrosation of nitrosothiols: Characterization of an elusive intermediate

We report an investigation of the reaction between (S)-nitroso-L-cysteine ethyl ester and L-cysteine ethyl ester as a model of physiologically relevant transnitrosation processes. Our theoretical and experimental evidence clearly supports the existence of a nitroxyl disulfide intermediate in solutio...

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Detalles Bibliográficos
Autores principales: Perissinotti, L.L., Turjanski, A.G., Estrin, D.A., Doctorovich, F.
Formato: JOUR
Materias:
nitrosocysteine ethylester
thiol derivative
unclassified drug
article
chemical reaction kinetics
geometry
nitrogen nuclear magnetic resonance
nitrosation
nuclear magnetic resonance spectroscopy
proton nuclear magnetic resonance
thermodynamics
transnitrosation
Cysteine
Kinetics
Magnetic Resonance Spectroscopy
Models, Molecular
Nitrosation
Nitroso Compounds
Thermodynamics
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v127_n2_p486_Perissinotti
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We report an investigation of the reaction between (S)-nitroso-L-cysteine ethyl ester and L-cysteine ethyl ester as a model of physiologically relevant transnitrosation processes. Our theoretical and experimental evidence clearly supports the existence of a nitroxyl disulfide intermediate in solution. Copyright © 2005 American Chemical Society.

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