Theoretical study of the truncated hemoglobin HbN: Exploring the molecular basis of the NO detoxification mechanism

Mycobacterium tuberculosis is the causative agent of human tuberculosis. The nitric oxide reaction with oxy-truncated hemoglobin N (IrHbN) has been proposed to be responsible for the resistance mechanism by which this microorganism can evade the toxic effects of NO. In this work, we explore the mole...

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Detalles Bibliográficos
Autores principales: Crespo, A., Martí, M.A., Kalko, S.G., Morreale, A., Orozco, M., Gelpi, J.L., Luque, F.J., Estrin, D.A.
Formato: JOUR
Materias:
Bacteria
Computer simulation
Diffusion
Diseases
Microorganisms
Proteins
Quantum theory
Reaction kinetics
Toxicity
Detoxifications
Mycobacterium tuberculosis
Nitric oxides
Toxic effects
Nitrogen compounds
glycine
hemoglobin
ligand
nitric oxide
tyrosine
article
bacterial infection
binding site
cell survival
detoxification
enzyme active site
gene rearrangement
molecular dynamics
quantum theory
simulation
tuberculosis
Heme
Hemoglobins
Metabolic Detoxication, Drug
Models, Molecular
Nitric Oxide
Oxidation-Reduction
Oxygen
Protein Conformation
Quantum Theory
Thermodynamics
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00027863_v127_n12_p4433_Crespo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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