Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice

Therapeutic failures attributed to medical management of cystic echinococcosis (CE) with albendazole (ABZ) have been primarily linked to the poor drug absorption rate resulting in low drug level in plasma and hydatid cysts. Lipid nanocapsules (LNCs) represent nanocarriers designed to encapsulate lip...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Pensel, P.E., Ullio Gamboa, G., Fabbri, J., Ceballos, L., Sanchez Bruni, S., Alvarez, L.I., Allemandi, D., Benoit, J.P., Palma, S.D., Elissondo, M.C.
Formato: JOUR
Materias:
Albendazole
Cystic echinococcosis
Echinococcus granulosus
Lipid nanocapsules
albendazole
lipid nanocapsule
nanocapsule
unclassified drug
anthelmintic agent
lipid
bioavailability
concentration (composition)
drug
medical geography
parasitic disease
rodent
animal experiment
animal model
area under the curve
Article
controlled study
drug bioavailability
drug blood level
drug dosage form comparison
drug efficacy
drug exposure
drug formulation
echinococcosis
female
in vitro study
maximum plasma concentration
mouse
nanoencapsulation
nonhuman
time to maximum plasma concentration
animal
drug delivery system
medicinal chemistry
oral drug administration
Animalia
Mus
Administration, Oral
Animals
Anthelmintics
Biological Availability
Chemistry, Pharmaceutical
Drug Delivery Systems
Echinococcosis
Female
Lipids
Mice
Nanocapsules
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0001706X_v152_n_p185_Pensel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares