Modulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2α, which Is Relevant during Hypoxia

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The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied independently. Here, we asked whether the Akt pathway regulates the UPR. To...

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Detalles Bibliográficos
Autores principales: Blaustein, M., Pérez-Munizaga, D., Sánchez, M.A., Urrutia, C., Grande, A., Risso, G., Srebrow, A., Alfaro, J., Colman-Lerner, A.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2013
Materias:
activating transcription factor 6
cell protein
initiation factor 2alpha
inositol requiring protein 1
PERK protein
phosphatidylinositol 3 kinase
protein kinase B
unclassified drug
article
cell death
cell fate
controlled study
human
human cell
hypoxia
physiological process
protein phosphorylation
protein protein interaction
protein targeting
protein unfolding
signal transduction
Cell Hypoxia
Cell Line
Cell Line, Tumor
Cell Survival
eIF-2 Kinase
Eukaryotic Initiation Factor-2
HeLa Cells
Humans
Proto-Oncogene Proteins c-akt
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v8_n7_p_Blaustein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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