Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia

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Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate oxygen-dependent HIF regulation operate at the level of the alpha subunit, con...

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Detalles Bibliográficos
Autores principales: Dekanty, A., Romero, N.M., Bertolin, A.P., Thomas, M.G., Leishman, C.C., Perez-Perri, J.I., Boccaccio, G.L., Wappner, P.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
argonaute 1 protein
hypoxia inducible factor
microRNA
argonaute1 protein, Drosophila
basic helix loop helix transcription factor
Drosophila protein
initiation factor
animal cell
article
controlled study
Drosophila melanogaster
gene identification
genetic screening
genomics
hypoxia
nonhuman
RNA interference
transcription regulation
animal
anoxia
cell line
genetic association
genetic transcription
genetics
metabolism
Animals
Anoxia
Basic Helix-Loop-Helix Transcription Factors
Cell Line
Drosophila Proteins
Eukaryotic Initiation Factors
Genome-Wide Association Study
RNA Interference
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15537390_v6_n6_p1_Dekanty
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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