Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene

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The proopiomelanocortin gene (POMC) is expressed in the pituitary gland and the ventral hypothalamus of all jawed vertebrates, producing several bioactive peptides that function as peripheral hormones or central neuropeptides, respectively. We have recently determined that mouse and human POMC expre...

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Detalles Bibliográficos
Autores principales: Santangelo, A.M., De Souza, F.S.J., Franchini, L.F., Bumaschny, V.F., Low, M.J., Rubinstein, M.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2007
Materias:
proopiomelanocortin
animal experiment
animal tissue
article
brain nerve cell
computer model
embryo
enhancer region
female
gene expression
genetic conservation
genetic database
genetic line
genome analysis
hypothalamus
intron
mammalian genetics
marsupial
molecular evolution
monotremate
mouse
multigene family
newborn
nonhuman
physical anthropology
placenta
reporter gene
retroposon
short interspersed repeat
transposon
vertebrate
Animals
Base Sequence
Computational Biology
Consensus Sequence
Conserved Sequence
Embryonic Development
Enhancer Elements (Genetics)
Evolution, Molecular
Gene Expression Regulation, Developmental
Genomics
Mammals
Mice
Mice, Transgenic
Molecular Sequence Data
Neurons
Opossums
Paleontology
Pro-Opiomelanocortin
Sequence Alignment
Sequence Analysis, DNA
Sequence Deletion
Short Interspersed Nucleotide Elements
Didelphidae
Eutheria
Gnathostomata (vertebrate)
Mammalia
Metatheria
Monotremata
Mus musculus
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15537390_v3_n10_p1813_Santangelo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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