A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10-1082 promoter genotype as predictor of disease progression

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Background: Sixteen melanoma patients (1 stage IIC, 8 stage III, and 7 stage IV) were treated in a Phase I study with a vaccine (DC/Apo-Nec) composed of autologous dendritic cells (DCs) loaded with a mixture of apoptotic/necrotic allogeneic melanoma cell lines (Apo-Nec), to evaluate toxicity and imm...

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Detalles Bibliográficos
Autores principales:	von Euw, E.M., Barrio, M.M., Furman, D., Levy, E.M., Bianchini, M., Peguillet, I., Lantz, O., Vellice, A., Kohan, A., Chacón, M., Yee, C., Wainstok, R., Mordoh, J.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2008
Materias:	alpha interferon B7 antigen CD8 antigen CD83 antigen CD86 antigen chemokine receptor CCR7 dendritic cell vaccine dextran fluorescein isothiocyanate glycoprotein gp 100 granulocyte macrophage colony stimulating factor HLA A antigen HLA antigen class 1 HLA antigen class 2 interleukin 10 interleukin 4 macrophage inflammatory protein 3beta melan A melanoma antigen tetramer cancer vaccine abdominal cramp abdominal pain adolescent adult anorexia antigen expression apoptosis article asthenia cancer staging CD8+ T lymphocyte cell culture cell death cell maturation cell migration cell stimulation chill clinical trial controlled clinical trial controlled study correlation analysis culture medium cytokine production dendritic cell diarrhea disease course drug safety drug tolerability endocytosis enzyme linked immunospot assay fatigue female follow up gamma radiation genetic polymorphism genotype headache human human cell humoral immunity immune response in vitro study injection site reaction leukapheresis liver dysfunction lymph node dissection lymphocyte proliferation male melanoma melanoma cell monocyte myalgia nausea peripheral blood mononuclear cell phagocytosis phase 1 clinical trial polymerase chain reaction prediction prognosis promoter region treatment outcome tumor immunity upregulation vomiting autotransplantation delayed hypersensitivity genetics immunology lymphocyte activation middle aged necrosis pathology patient selection prediction and forecasting transplantation Adolescent Adult Apoptosis Cancer Vaccines Dendritic Cells Disease Progression Female Genotype Humans Hypersensitivity, Delayed Interleukin-10 Lymphocyte Activation Male Melanoma Middle Aged Necrosis Neoplasm Staging Patient Selection Phagocytosis Polymorphism, Genetic Predictive Value of Tests Promoter Regions (Genetics) Transplantation, Autologous
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14795876_v6_n_p_vonEuw
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires