Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B

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Background: Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity. The insulin receptor (IR) binds insulin and IGFs with different affinities triggering different cell respon...

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Detalles Bibliográficos
Autores principales: Giudice, J., Barcos, L.S., Guaimas, F.F., Penas-Steinhardt, A., Giordano, L., Jares-Erijman, E.A., Coluccio Leskow, F.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2013
Materias:
Endocytosis
Insulin receptor
Insulin/IGF-II
Microscopy
Quantum dots
Signaling
cyan fluorescent protein
insulin
insulin receptor
insulin receptor B
quantum dot
somatomedin B
streptavidin
unclassified drug
article
biotinylation
cell membrane
cell proliferation
confocal microscopy
controlled study
endocytosis
endosome
flow cytometry
gene overexpression
genetic transcription
human
human cell
internalization
metabolic regulation
mitogenesis
priority journal
protein interaction
receptor binding
receptor upregulation
signal transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1478811X_v11_n1_p_Giudice
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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