BRCA1 and p53 regulate critical prostate cancer pathways

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Background:Loss or mutations of the BRCA1 gene are associated with increased risk of breast and ovarian cancers and with prostate cancer (PCa) aggressiveness. Previously, we identified GADD153 as a target of BRCA1 protein, which increases doxorubicin sensitivity in human p53 -/- PCa cells (PC3). Con...

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Detalles Bibliográficos
Autores principales:	De Luca, P., Moiola, C.P., Zalazar, F., Gardner, K., Vazquez, E.S., De Siervi, A.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2013
Materias:	BRCA1 DNA damage GADD153 p53 beta catenin Bloom syndrome helicase BRCA1 protein BRCA2 protein cyclin D1 cyclin dependent kinase inhibitor 1 fibronectin growth arrest and DNA damage inducible protein 153 luciferase protein p53 protein Patched 1 sonic hedgehog protein transcription factor Gli1 transcription factor Slug transcription factor Snail uvomorulin vimentin actin B gene animal experiment animal model animal tissue article beta catenin gene BLM gene CCNB2 gene cell cycle regulation cell strain LNCaP chromatin immunoprecipitation controlled study Cyclin D1 gene DDB2 gene E cadherin gene enzyme assay epithelial mesenchymal transition FEN1 gene fibronectin gene GADD153 gene Gadd45a gene gene gene expression GLI1 gene H3F3B gene in vivo study male mouse nonhuman p21 WAF1 CIP1 gene patch1 gene priority journal prostate cancer protein expression quantitative analysis reverse transcription polymerase chain reaction SHH gene Slug gene Snail gene transcription regulation tumor suppressor gene Vimentin gene Western blotting Animals BRCA1 Protein Cell Cycle Cell Line, Tumor DNA Damage Hedgehogs Heterografts Humans Male Mice Prostatic Neoplasms Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Transcription Factor CHOP Transcription, Genetic Tumor Suppressor Protein p53
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_13657852_v16_n3_p233_DeLuca
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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