The role of deadenylation in the degradation of unstable mRNAs in trypanosomes

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Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1/Not complex has the predominant deadenylase activity, while the Pan2/Pan3 complex may trim poly(A) tails to the correct size, or initiate deadenylation. In trypanosomes, t...

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Detalles Bibliográficos
Autores principales: Schwede, A., Manful, T., Jha, B.A., Helbig, C., Bercovich, N., Stewart, M., Clayton, C.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2009
Materias:
chromatin assembly factor 1
gene product
messenger RNA
protein EP
ribosome protein
unclassified drug
EP procyclin protein, Trypanosoma brucei
membrane protein
mRNA deadenylase
phosphoglycerate kinase
protozoal protein
ribonuclease
3' untranslated region
5' untranslated region
adenylation
article
controlled study
cytoplasm
gene amplification
gene sequence
nonhuman
priority journal
protein depletion
protein targeting
RNA degradation
RNA interference
Trypanosoma
animal
chemistry
drug antagonism
enzymology
genetics
genome
growth, development and aging
metabolism
physiology
RNA stability
Eukaryota
Metazoa
Animals
Cytoplasm
Genome, Protozoan
Membrane Glycoproteins
Phosphoglycerate Kinase
Protozoan Proteins
Ribonucleases
RNA Interference
RNA Stability
RNA, Messenger
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03051048_v37_n16_p5511_Schwede
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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