Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP α2-chimaerin

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Chimaerins are a family of GTPase activating proteins (GAPs) for the small G-protein Rac that have gained recent attention due to their important roles in development, cancer, neuritogenesis, and T-cell function. Like protein kinase C isozymes, chimaerins possess a C1 domain capable of binding phorb...

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Detalles Bibliográficos
Autores principales: Colón-González, F., Leskow, F.C., Kazanietz, M.G.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2008
Materias:
Amines
Amino acids
Binding energy
Binding sites
Bioactivity
Biochemistry
Cell membranes
Cytology
Esterification
Esters
Gallium alloys
Glycerol
Growth (materials)
Ligands
Organic acids
Organic compounds
Peptides
Pneumatic control equipment
Activating proteins
C1 domains
Cell functions
Cell migrations
Diacylglycerol
Epidermal growth factors
In vitro
Inactive conformations
Ligand bindings
Lipid second messengers
Membrane associations
Modeling analysis
Neuritogenesis
Phorbol esters
Phospholipase
Plasma membranes
Protein kinases
Terminal regions
Chemical activation
chimerin
chimerin alpha 2
epidermal growth factor
guanosine triphosphatase activating protein
phorbol 13 acetate 12 myristate
Rac protein
unclassified drug
article
binding site
cell membrane
human
human cell
priority journal
protein analysis
protein domain
protein function
protein localization
Animals
Cercopithecus aethiops
Chimerin 1
COS Cells
Epidermal Growth Factor
GTPase-Activating Proteins
Hela Cells
Humans
Mutation
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Protein Transport
rac GTP-Binding Proteins
Type C Phospholipases
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v283_n50_p35247_ColonGonzalez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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