Generation of Sequence-specific, High Affinity Anti-DNA Antibodies

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By taking advantage of the extreme stability of a protein-DNA complex, we have obtained two highly specific monoclonal antibodies against a predetermined palindromic DNA sequence corresponding to the binding site of the E2 transcriptional regulator of the human papillomavirus (HPV-16). The purified...

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Detalles Bibliográficos
Autores principales:	Cerutti, M.L., Centeno, J.M., Goldbaum, F.A., De Prat-Gay, G.
Formato:	Artículo publishedVersion
Lenguaje:	Inglés
Publicado:	2001
Materias:	Antigens Chemical bonds Complexation Dissociation DNA DNA sequences Spectroscopy Dissociation constants Antibodies DNA antibody oligonucleotide transcription factor E2 unclassified drug DNA binding protein E2 protein, Bovine papillomavirus E2 protein, Human papillomavirus type 16 monoclonal antibody oncoprotein virus protein antibody specificity antigen binding antigen recognition article binding affinity binding assay binding site carboxy terminal sequence complex formation dissociation constant DNA binding DNA sequence immunogenicity priority journal protein DNA binding protein DNA interaction spectroscopy transcription regulation amino acid sequence animal antibody combining site cattle chemistry enzyme linked immunosorbent assay human immunoglobulin variable region immunology metabolism molecular genetics mouse Papilloma virus sequence alignment sequence homology Bovinae Human papillomavirus Human papillomavirus type 16 Papillomavirus Amino Acid Sequence Animals Antibodies, Monoclonal Binding Sites Binding Sites, Antibody Cattle DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin Variable Region Mice Molecular Sequence Data Oncogene Proteins, Viral Papillomaviridae Sequence Alignment Sequence Homology, Amino Acid Viral Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219258_v276_n16_p12769_Cerutti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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