Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I

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1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2....

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Detalles Bibliográficos
Autores principales: Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 1987
Materias:
hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.

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