Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways

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Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor. However, pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in placenta, where it was found to be expressed. I...

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Detalles Bibliográficos
Autores principales: Maymó, J.L., Pérez, A.P., Dueñas, J.L., Calvo, J.C., Sánchez-Margalet, V., Varone, C.L.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2010
Materias:
2 (2 amino 3 methoxyphenyl)chromone
adenylate cyclase
bucladesine
cyclic AMP
cyclic AMP dependent protein kinase
cyclic AMP responsive element binding protein
leptin
mitogen activated protein kinase 1
mitogen activated protein kinase 3
article
concentration response
controlled study
enzyme active site
enzyme inhibition
explant
gene activity
hormone release
human
human cell
human tissue
physiological process
placenta
plasmid
priority journal
promoter region
protein phosphorylation
regulatory mechanism
reporter gene
reverse transcription polymerase chain reaction
signal transduction
transient transfection
trophoblast
upregulation
Western blotting
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v151_n8_p3738_Maymo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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