Involvement of Bax Protein in the Prevention of Glucocorticoid-Induced Thymocytes Apoptosis by Melatonin

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The antiapoptotic effect of melatonin has been described in several systems. In this study, the antagonistic effect of the methoxyindole on dexamethasone-induced apoptosis in mouse thymocytes was examined. Melatonin decreased both DNA fragmentation, and the number of annexin V-positive cells incubat...

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Detalles Bibliográficos
Autores principales: Hoijman, E., Rocha Viegas, L., Keller Sarmiento, M.I., Rosenstein, R.E., Pecci, A.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2004
Materias:
cytochrome c
dexamethasone
DNA fragment
glucocorticoid
lipocortin 5
melatonin
protein Bak
protein Bax
protein bcl 2
protein bcl xl
animal cell
animal experiment
animal model
apoptosis
article
cell death
cellular distribution
controlled study
drug induced disease
enzyme activation
gene overexpression
male
mitochondrial membrane
mouse
nonhuman
outer membrane
priority journal
protein analysis
protein family
protein synthesis regulation
receptor density
thymocyte
thymus
Adjuvants, Immunologic
Animals
Apoptosis
bcl-2-Associated X Protein
Cytochromes c
Dexamethasone
Glucocorticoids
Male
Melatonin
Mice
Mice, Inbred Strains
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Receptors, Glucocorticoid
RNA, Messenger
Thymus Gland
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v145_n1_p418_Hoijman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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