Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse

The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation of mRNA-silencing foci, including Processing Bodies (PBs) and Stress Granules (...

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Autores principales: Luchelli, Luciana, Habif, Martín, Boccaccio, Graciela Lidia
Publicado: 2012
Materias:
CPEB
FMRP
FUS/TLS
mRNA silencing
P-Bodies
Pumilio
RNG105
SAMD4
Smaug
Stress granules
TDP43
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v5_n4_p388_Pascual
http://hdl.handle.net/20.500.12110/paper_19420889_v5_n4_p388_Pascual
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_19420889_v5_n4_p388_Pascual
record_format dspace
spelling paper:paper_19420889_v5_n4_p388_Pascual2023-06-08T16:32:22Z Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse Luchelli, Luciana Habif, Martín Boccaccio, Graciela Lidia CPEB FMRP FUS/TLS mRNA silencing P-Bodies Pumilio RNG105 SAMD4 Smaug Stress granules TDP43 The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation of mRNA-silencing foci, including Processing Bodies (PBs) and Stress Granules (SGs), which are macromolecular aggregates that harbor silenced messengers and associated proteins. In a recent work, we identified a kind of mRNA-silencing foci unique to neurons, termed S-foci, that contain the posttranscriptional regulator Smaug1/ SAMD4. Upon specific synaptic stimulation, the S-foci dissolve and release mRNAs to allow their translation, paralleling the cycling of mRNAs between PBs and polysomes in other cellular contexts. Smaug 1 and other proteins involved in mRNA regulation in neurons contain aggregation domains distinct from their RNA binding motifs, and we speculate that self-aggregation helps silencing and transport. In addition to S-foci and PBs, other foci formed by distinct RNA binding proteins, such as TDP-43 and FMRP among others, respond dynamically to specific synaptic stimuli. We propose the collective name of synaptic activity-regulated mRNA silencing (SyAS) foci for these RNP aggregates that selectively respond to distinct stimulation patterns and contribute to the fine-tuning of local protein synthesis at the synapse. © 2012 Landes Bioscience. Fil:Luchelli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Habif, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v5_n4_p388_Pascual http://hdl.handle.net/20.500.12110/paper_19420889_v5_n4_p388_Pascual
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic CPEB
FMRP
FUS/TLS
mRNA silencing
P-Bodies
Pumilio
RNG105
SAMD4
Smaug
Stress granules
TDP43
spellingShingle CPEB
FMRP
FUS/TLS
mRNA silencing
P-Bodies
Pumilio
RNG105
SAMD4
Smaug
Stress granules
TDP43
Luchelli, Luciana
Habif, Martín
Boccaccio, Graciela Lidia
Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
topic_facet CPEB
FMRP
FUS/TLS
mRNA silencing
P-Bodies
Pumilio
RNG105
SAMD4
Smaug
Stress granules
TDP43
description The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation of mRNA-silencing foci, including Processing Bodies (PBs) and Stress Granules (SGs), which are macromolecular aggregates that harbor silenced messengers and associated proteins. In a recent work, we identified a kind of mRNA-silencing foci unique to neurons, termed S-foci, that contain the posttranscriptional regulator Smaug1/ SAMD4. Upon specific synaptic stimulation, the S-foci dissolve and release mRNAs to allow their translation, paralleling the cycling of mRNAs between PBs and polysomes in other cellular contexts. Smaug 1 and other proteins involved in mRNA regulation in neurons contain aggregation domains distinct from their RNA binding motifs, and we speculate that self-aggregation helps silencing and transport. In addition to S-foci and PBs, other foci formed by distinct RNA binding proteins, such as TDP-43 and FMRP among others, respond dynamically to specific synaptic stimuli. We propose the collective name of synaptic activity-regulated mRNA silencing (SyAS) foci for these RNP aggregates that selectively respond to distinct stimulation patterns and contribute to the fine-tuning of local protein synthesis at the synapse. © 2012 Landes Bioscience.
author Luchelli, Luciana
Habif, Martín
Boccaccio, Graciela Lidia
author_facet Luchelli, Luciana
Habif, Martín
Boccaccio, Graciela Lidia
author_sort Luchelli, Luciana
title Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
title_short Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
title_full Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
title_fullStr Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
title_full_unstemmed Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
title_sort synaptic activity regulated mrna-silencing foci for the fine tuning of local protein synthesis at the synapse
publishDate 2012
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v5_n4_p388_Pascual
http://hdl.handle.net/20.500.12110/paper_19420889_v5_n4_p388_Pascual
work_keys_str_mv AT luchelliluciana synapticactivityregulatedmrnasilencingfociforthefinetuningoflocalproteinsynthesisatthesynapse
AT habifmartin synapticactivityregulatedmrnasilencingfociforthefinetuningoflocalproteinsynthesisatthesynapse
AT boccacciogracielalidia synapticactivityregulatedmrnasilencingfociforthefinetuningoflocalproteinsynthesisatthesynapse
_version_ 1768542102764912640

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