Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis

Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a mitochondrial dynamics impairment and may promote apoptosis. Increasing evidence corre...

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Detalles Bibliográficos
Autores principales: Alaimo, Agustina, Muñoz, Manuel Javier, Kotler, Mónica Lidia
Publicado: 2014
Materias:
manganese
mitochondrial protein
protein Drp 1
protein Opa 1
small interfering RNA
unclassified drug
animal cell
animal experiment
animal model
animal tissue
apoptosis
article
astrocyte
basal ganglion
bioaccumulation
brain region
cell disruption
cellular distribution
controlled study
cytosol
cytotoxicity
disorders of mitochondrial functions
male
molecular dynamics
nonhuman
parkinsonism
protein analysis
protein expression
protein function
protein localization
protein transport
rat
toxicity testing
upregulation
Animals
Apoptosis
Cell Line, Tumor
Cyclosporine
Dynamins
Gene Expression Regulation
GTP Phosphohydrolases
Intracellular Space
Male
Manganese
Membrane Potential, Mitochondrial
Mitochondria
Neostriatum
Protein Transport
Rats
Rats, Sprague-Dawley
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v9_n3_p_Alaimo
http://hdl.handle.net/20.500.12110/paper_19326203_v9_n3_p_Alaimo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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