Synthesis and evaluation of 1,1′-hydrocarbylenebis(indazol-3-ols) as potential antimalarial drugs

Bis(indazol-3-ol) derivatives (5, 30-38) were prepared by alkylation of 3-alkoxyindazoles with α,ω-dibromides, followed by removal of the O-protecting groups. These compounds were subsequently evaluated as inhibitors of biocrystallization of ferriproto-porphyrin IX (heme) to hemozoin, a Plasmodium d...

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Guardado en:
Detalles Bibliográficos
Publicado: 2009
Materias:
Alkylation
Antimalarial agents
Drug design
Inhibitors
Nitrogen heterocycles
1,1 hydrocarbylenebis(inidazol 3 ols)
1,1 tetramethylenebis(5 nitro 1h indazol 3 ol)
1,1' (2 xylylene)bis(1h indazol 3 ol)
1,1' (3 xylylene)bis(5 nitro 1h indazol 3 ol)
1,1' (4 xylylene)bis(5 nitro 1h indazol 3 ol)
1,1' [(2,2 diphenyldiyl)bismethylene]bis(5 nitro 1h indazol 3 ol)
1,1' [(2,6 pyridinediyl)bismethylene]bis(5 nitro 1h indazol 3 ol)
1,1' ethylenebis(5 nitro 1h indazol 3 ol)
1,1' hexamethylenebis(5 nitro 1h indazol 3 ol)
1,1' pentamethylenebis(5 nitro 1h indazol 3 ol)
3 alkoxyindazole derivative
alpha omega dibromide derivative
antimalarial agent
bis(5 nitroindazol ols)
bromine derivative
hematin
hemozoin
indazole derivative
unclassified drug
alkylation
antimalarial activity
article
chemical reaction
detoxification
drug screening
drug structure
drug synthesis
Plasmodium
priority journal
Animals
Antimalarials
Hemeproteins
Hemin
Indazoles
Inhibitory Concentration 50
Mice
Plasmodium berghei
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18607179_v4_n1_p78_Alho
http://hdl.handle.net/20.500.12110/paper_18607179_v4_n1_p78_Alho
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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