Plasma homocysteine cutoff values for venous thrombosis

Background: Hyperhomocysteinemia is considered an independent risk factor for vascular occlusive diseases. To date, there is no general agreement on hyperhomocysteinemia cutoff values. Methods: To establish a homocysteine cutoff value, we performed a case-control study in 118 patients suffering from...

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Autores principales:	Castañon, María Mercedes, Lauricella, Ana María, Kordich, Lucía Clelia, Quintana, Irene Luisa
Publicado:	2007
Materias:	Cutoff values Hyperhomocysteinemia Venous thrombosis 5,10 methylenetetrahydrofolate reductase (FADH2) homocysteine adult article controlled study disease association female human hyperhomocysteinemia major clinical study male priority journal risk factor statistical significance vein thrombosis Adult Case-Control Studies Female Homocysteine Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Odds Ratio Venous Thrombosis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v45_n2_p232_Castanon http://hdl.handle.net/20.500.12110/paper_14346621_v45_n2_p232_Castanon
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_14346621_v45_n2_p232_Castanon
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spelling	paper:paper_14346621_v45_n2_p232_Castanon2023-06-08T16:15:37Z Plasma homocysteine cutoff values for venous thrombosis Castañon, María Mercedes Lauricella, Ana María Kordich, Lucía Clelia Quintana, Irene Luisa Cutoff values Hyperhomocysteinemia Venous thrombosis 5,10 methylenetetrahydrofolate reductase (FADH2) homocysteine adult article controlled study disease association female human hyperhomocysteinemia major clinical study male priority journal risk factor statistical significance vein thrombosis Adult Case-Control Studies Female Homocysteine Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Odds Ratio Venous Thrombosis Background: Hyperhomocysteinemia is considered an independent risk factor for vascular occlusive diseases. To date, there is no general agreement on hyperhomocysteinemia cutoff values. Methods: To establish a homocysteine cutoff value, we performed a case-control study in 118 patients suffering from venous thrombosis and in 115 healthy subjects. We calculated odds ratios at different cutoff points and considered hyperhomocysteinemia as homocysteine levels above which the risk of venous thrombosis was increased. Results: Initially we used the 97.5th percentiles for fasting homocysteine levels in the control group to calculate odds ratios (95% CI) of 9.5 (2.6-35.3), 3.7 (0.8-17.9) and 4.5 (1.7-123.8) for the total population, women and men, respectively. When individuals with well-known thrombotic risk factors were excluded (selected population), odds ratios were 10.5 (2.7- 41.1), 6.5 (1.3-32.1) and 11.2 (1.2-103.1), respectively, confirming hyperhomocysteinemia as an independent risk factor for venous thrombosis. We did not find any association of venous thrombosis with the homozygous methylenetetrahydrofolate reductase C677T mutation. When the hyperhomocysteinemia cutoff was set at other arbitrary points, odds ratios for the selected population were statistically significant only at >12 μmol/L. Conclusions: Based on our results, we propose 12 μmol/L as the hyperhomocysteinemia cutoff value. © 2007 by Walter de Gruyter. Fil:Castañon, M.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v45_n2_p232_Castanon http://hdl.handle.net/20.500.12110/paper_14346621_v45_n2_p232_Castanon
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cutoff values Hyperhomocysteinemia Venous thrombosis 5,10 methylenetetrahydrofolate reductase (FADH2) homocysteine adult article controlled study disease association female human hyperhomocysteinemia major clinical study male priority journal risk factor statistical significance vein thrombosis Adult Case-Control Studies Female Homocysteine Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Odds Ratio Venous Thrombosis
spellingShingle	Cutoff values Hyperhomocysteinemia Venous thrombosis 5,10 methylenetetrahydrofolate reductase (FADH2) homocysteine adult article controlled study disease association female human hyperhomocysteinemia major clinical study male priority journal risk factor statistical significance vein thrombosis Adult Case-Control Studies Female Homocysteine Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Odds Ratio Venous Thrombosis Castañon, María Mercedes Lauricella, Ana María Kordich, Lucía Clelia Quintana, Irene Luisa Plasma homocysteine cutoff values for venous thrombosis
topic_facet	Cutoff values Hyperhomocysteinemia Venous thrombosis 5,10 methylenetetrahydrofolate reductase (FADH2) homocysteine adult article controlled study disease association female human hyperhomocysteinemia major clinical study male priority journal risk factor statistical significance vein thrombosis Adult Case-Control Studies Female Homocysteine Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Odds Ratio Venous Thrombosis
description	Background: Hyperhomocysteinemia is considered an independent risk factor for vascular occlusive diseases. To date, there is no general agreement on hyperhomocysteinemia cutoff values. Methods: To establish a homocysteine cutoff value, we performed a case-control study in 118 patients suffering from venous thrombosis and in 115 healthy subjects. We calculated odds ratios at different cutoff points and considered hyperhomocysteinemia as homocysteine levels above which the risk of venous thrombosis was increased. Results: Initially we used the 97.5th percentiles for fasting homocysteine levels in the control group to calculate odds ratios (95% CI) of 9.5 (2.6-35.3), 3.7 (0.8-17.9) and 4.5 (1.7-123.8) for the total population, women and men, respectively. When individuals with well-known thrombotic risk factors were excluded (selected population), odds ratios were 10.5 (2.7- 41.1), 6.5 (1.3-32.1) and 11.2 (1.2-103.1), respectively, confirming hyperhomocysteinemia as an independent risk factor for venous thrombosis. We did not find any association of venous thrombosis with the homozygous methylenetetrahydrofolate reductase C677T mutation. When the hyperhomocysteinemia cutoff was set at other arbitrary points, odds ratios for the selected population were statistically significant only at >12 μmol/L. Conclusions: Based on our results, we propose 12 μmol/L as the hyperhomocysteinemia cutoff value. © 2007 by Walter de Gruyter.
author	Castañon, María Mercedes Lauricella, Ana María Kordich, Lucía Clelia Quintana, Irene Luisa
author_facet	Castañon, María Mercedes Lauricella, Ana María Kordich, Lucía Clelia Quintana, Irene Luisa
author_sort	Castañon, María Mercedes
title	Plasma homocysteine cutoff values for venous thrombosis
title_short	Plasma homocysteine cutoff values for venous thrombosis
title_full	Plasma homocysteine cutoff values for venous thrombosis
title_fullStr	Plasma homocysteine cutoff values for venous thrombosis
title_full_unstemmed	Plasma homocysteine cutoff values for venous thrombosis
title_sort	plasma homocysteine cutoff values for venous thrombosis
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v45_n2_p232_Castanon http://hdl.handle.net/20.500.12110/paper_14346621_v45_n2_p232_Castanon
work_keys_str_mv	AT castanonmariamercedes plasmahomocysteinecutoffvaluesforvenousthrombosis AT lauricellaanamaria plasmahomocysteinecutoffvaluesforvenousthrombosis AT kordichluciaclelia plasmahomocysteinecutoffvaluesforvenousthrombosis AT quintanaireneluisa plasmahomocysteinecutoffvaluesforvenousthrombosis
_version_	1768543198585552896

Plasma homocysteine cutoff values for venous thrombosis

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