Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone

3α-Hydroxy-2,19-oxido-5αH-pregnan-20-one was synthesized in 6 steps from the easily available 19-hydroxypregnenolone 3-acetate. The 2,19-oxido bridge was formed in a single step upon spontaneous cyclization and desilylation of a TBDMS protected 19-hydroxy-2α,3α-epoxypregnane. The 4,19-oxido analogue...

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Detalles Bibliográficos
Autores principales:	Ghini, Alberto Antonio, Burton, Gerardo
Publicado:	2003
Materias:	2,19-Oxido-allopregnanolone 4,19-oxido-allopregnanolone Neurosteroid Oxido-bridged steroid 19 hydroxy 2alpha,3alpha epoxypregnane 19 hydroxypregnenolone 3 acetate 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one 3alpha hydroxy 5alphah pregnan 20 one 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one bridged compound neurosteroid silane derivative unclassified drug article cyclization desilylation drug structure drug synthesis structure activity relation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p468_Eduardo http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p468_Eduardo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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