21-hydroxy-6,19-epoxyprogesterone: A promising therapeutic agent and a molecular tool for deciphering glucocorticoid action

Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR), a ligand regulated transcription factor. Although glucocorticoids are widely used in the clinic, their usage in chronic therapies provokes severe adverse reactions. In the...

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Detalles Bibliográficos
Autores principales: Pecci, Adali, Presman, Diego Martín, Burton, Gerardo
Publicado: 2016
Materias:
21-hydroxy-6,19-epoxyprogesterone
Dissociated ligands
Glucocorticoid mechanism of action
Glucocorticoid receptor
Molecular dynamics
Rigid steroids
21 hydroxy 6 19 epoxyprogesterone
dexamethasone
glucocorticoid
mifepristone
paclitaxel
progesterone derivative
unclassified drug
21-hydroxy-6,19-oxidoprogesterone
glucocorticoid receptor
immunosuppressive agent
nonsteroid antiinflammatory agent
progesterone
anxiety
apoptosis
biological activity
breast cancer
conformational transition
crystal structure
depression
dimerization
gene expression
gene overexpression
hydrogen bond
hypertension
immunosurveillance
inflammation
ligand binding
lung cancer
molecular biology
molecular docking
molecular dynamics
oligomerization
point mutation
protein interaction
Review
spectroscopy
therapy effect
X ray crystallography
analogs and derivatives
chemical structure
chemistry
human
metabolism
molecular model
Anti-Inflammatory Agents, Non-Steroidal
Glucocorticoids
Humans
Immunosuppressive Agents
Models, Molecular
Molecular Structure
Progesterone
Receptors, Glucocorticoid
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895575_v16_n_p_Pecci
http://hdl.handle.net/20.500.12110/paper_13895575_v16_n_p_Pecci
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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