New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction
The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation, and thrombogenicity. Endothelium dysfunction, then, is considered to promote several disorders that initiate the atherosclerosis process. Vascular tone dysfunction can be determined by hig...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10752765_v15_n4_p340_Craiem http://hdl.handle.net/20.500.12110/paper_10752765_v15_n4_p340_Craiem |
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paper:paper_10752765_v15_n4_p340_Craiem2023-06-08T16:05:12Z New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction Age Endothelium Flow-mediated vasodilation Ultrasonography nitric oxide nitric oxide adult article atherosclerosis automation B scan blood flow blood vessel diameter blood vessel tone brachial angiography clinical article clinical assessment controlled study diastolic blood pressure endothelial dysfunction female human hyperemia image analysis male priority journal vasodilatation algorithm blood pressure brachial artery computer program echography forearm metabolism middle aged observer variation physiology reproducibility vascular endothelium vascularization vasodilatation Adult Algorithms Blood Pressure Brachial Artery Endothelium, Vascular Female Forearm Humans Male Middle Aged Nitric Oxide Observer Variation Regional Blood Flow Reproducibility of Results Software Vasodilation The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation, and thrombogenicity. Endothelium dysfunction, then, is considered to promote several disorders that initiate the atherosclerosis process. Vascular tone dysfunction can be determined by high-resolution ultrasonographic imaging of the brachial artery, enabling one to assess endothelium-dependent flow-mediated dilation (FMD). It is based on the principle that an increase in blood flow, specifically in shear stress, provokes the release of nitric oxide and then a vasodilation that can be quantified. In this study, brachial artery diameter evolution was continuously followed during baseline and hyperemia after forearm occlusion using a custom designed software. Some techniques used to measure FMD are limited by operator dependence. We present a new, automated, and versatile method of FMD quantification based on B-mode echographic images and edge detection algorithms. Edges for each image in the acquired sequences are recognized as interfaces based on the grey-level profiles of the averaged pixel values. Within-reading and within-subject FMD% coefficients of variation were 7% and 10%, respectively. This technique largely improves manual measurements and was shown to be appropriate for wide clinical use. © 2008 Lippincott Williams & Wilkins. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10752765_v15_n4_p340_Craiem http://hdl.handle.net/20.500.12110/paper_10752765_v15_n4_p340_Craiem |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Age Endothelium Flow-mediated vasodilation Ultrasonography nitric oxide nitric oxide adult article atherosclerosis automation B scan blood flow blood vessel diameter blood vessel tone brachial angiography clinical article clinical assessment controlled study diastolic blood pressure endothelial dysfunction female human hyperemia image analysis male priority journal vasodilatation algorithm blood pressure brachial artery computer program echography forearm metabolism middle aged observer variation physiology reproducibility vascular endothelium vascularization vasodilatation Adult Algorithms Blood Pressure Brachial Artery Endothelium, Vascular Female Forearm Humans Male Middle Aged Nitric Oxide Observer Variation Regional Blood Flow Reproducibility of Results Software Vasodilation |
| spellingShingle |
Age Endothelium Flow-mediated vasodilation Ultrasonography nitric oxide nitric oxide adult article atherosclerosis automation B scan blood flow blood vessel diameter blood vessel tone brachial angiography clinical article clinical assessment controlled study diastolic blood pressure endothelial dysfunction female human hyperemia image analysis male priority journal vasodilatation algorithm blood pressure brachial artery computer program echography forearm metabolism middle aged observer variation physiology reproducibility vascular endothelium vascularization vasodilatation Adult Algorithms Blood Pressure Brachial Artery Endothelium, Vascular Female Forearm Humans Male Middle Aged Nitric Oxide Observer Variation Regional Blood Flow Reproducibility of Results Software Vasodilation New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| topic_facet |
Age Endothelium Flow-mediated vasodilation Ultrasonography nitric oxide nitric oxide adult article atherosclerosis automation B scan blood flow blood vessel diameter blood vessel tone brachial angiography clinical article clinical assessment controlled study diastolic blood pressure endothelial dysfunction female human hyperemia image analysis male priority journal vasodilatation algorithm blood pressure brachial artery computer program echography forearm metabolism middle aged observer variation physiology reproducibility vascular endothelium vascularization vasodilatation Adult Algorithms Blood Pressure Brachial Artery Endothelium, Vascular Female Forearm Humans Male Middle Aged Nitric Oxide Observer Variation Regional Blood Flow Reproducibility of Results Software Vasodilation |
| description |
The vascular endothelium plays an important role in the regulation of vascular tone, cell growth, inflammation, and thrombogenicity. Endothelium dysfunction, then, is considered to promote several disorders that initiate the atherosclerosis process. Vascular tone dysfunction can be determined by high-resolution ultrasonographic imaging of the brachial artery, enabling one to assess endothelium-dependent flow-mediated dilation (FMD). It is based on the principle that an increase in blood flow, specifically in shear stress, provokes the release of nitric oxide and then a vasodilation that can be quantified. In this study, brachial artery diameter evolution was continuously followed during baseline and hyperemia after forearm occlusion using a custom designed software. Some techniques used to measure FMD are limited by operator dependence. We present a new, automated, and versatile method of FMD quantification based on B-mode echographic images and edge detection algorithms. Edges for each image in the acquired sequences are recognized as interfaces based on the grey-level profiles of the averaged pixel values. Within-reading and within-subject FMD% coefficients of variation were 7% and 10%, respectively. This technique largely improves manual measurements and was shown to be appropriate for wide clinical use. © 2008 Lippincott Williams & Wilkins. |
| title |
New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| title_short |
New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| title_full |
New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| title_fullStr |
New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| title_full_unstemmed |
New assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| title_sort |
new assessment of endothelium-dependent flow-mediated vasodilation to characterize endothelium dysfunction |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10752765_v15_n4_p340_Craiem http://hdl.handle.net/20.500.12110/paper_10752765_v15_n4_p340_Craiem |
| _version_ |
1768542999442096128 |