Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here...
Guardado en:
Autores principales: | , |
---|---|
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v133_n_p79_Krawczyk http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk |
Aporte de: |
id |
paper:paper_10747427_v133_n_p79_Krawczyk |
---|---|
record_format |
dspace |
spelling |
paper:paper_10747427_v133_n_p79_Krawczyk2023-06-08T16:05:03Z Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation Romano, Arturo Gabriel Feld, Mariana ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0 μg/hippocampus) 3 h after retrieval did not affect reconsolidation of a strong IA, when tested 24 h apart. However, the same manipulation impaired performance when animals were tested at 7 d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process. © 2016 Elsevier Inc. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Feld, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v133_n_p79_Krawczyk http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors |
spellingShingle |
ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors Romano, Arturo Gabriel Feld, Mariana Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
topic_facet |
ERK/MAPK Inhibitory avoidance Memory persistence Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one flavonoid mitogen activated protein kinase protein kinase inhibitor animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme activity enzyme inhibition footshock information retrieval long term memory male memory consolidation memory persistence mental function mental task mouse nonhuman task performance animal antagonists and inhibitors drug effects hippocampus long term memory memory consolidation metabolism physiology recall time factor Animals Avoidance Learning Extracellular Signal-Regulated MAP Kinases Flavonoids Hippocampus Memory Consolidation Memory, Long-Term Mental Recall Mice Protein Kinase Inhibitors Time Factors |
description |
Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0 μg/hippocampus) 3 h after retrieval did not affect reconsolidation of a strong IA, when tested 24 h apart. However, the same manipulation impaired performance when animals were tested at 7 d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process. © 2016 Elsevier Inc. |
author |
Romano, Arturo Gabriel Feld, Mariana |
author_facet |
Romano, Arturo Gabriel Feld, Mariana |
author_sort |
Romano, Arturo Gabriel |
title |
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
title_short |
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
title_full |
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
title_fullStr |
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
title_full_unstemmed |
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation |
title_sort |
reconsolidation-induced memory persistence: participation of late phase hippocampal erk activation |
publishDate |
2016 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v133_n_p79_Krawczyk http://hdl.handle.net/20.500.12110/paper_10747427_v133_n_p79_Krawczyk |
work_keys_str_mv |
AT romanoarturogabriel reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation AT feldmariana reconsolidationinducedmemorypersistenceparticipationoflatephasehippocampalerkactivation |
_version_ |
1768544330776051712 |