The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests
The reconsolidation process is the mechanism by which the strength and/or content of consolidated memories are updated. This process is triggered by the presentation of a reminder (training cues). It is not always possible to trigger the reconsolidation process. For example, memory age and strength...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v130_n_p202_Fernandez http://hdl.handle.net/20.500.12110/paper_10747427_v130_n_p202_Fernandez |
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paper:paper_10747427_v130_n_p202_Fernandez2023-06-08T16:05:02Z The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests Bavassi, Mariana Luz Forcato, Cecilia Pedreira, Maria Eugenia Boundary conditions Declarative memory Reconsolidation Social stress Strengthening Treatment outcome declarative memory human human experiment learning social interaction The reconsolidation process is the mechanism by which the strength and/or content of consolidated memories are updated. This process is triggered by the presentation of a reminder (training cues). It is not always possible to trigger the reconsolidation process. For example, memory age and strength are boundary conditions for the reconsolidation process. Here, we investigated the dynamic changes in these conditions. We propose that the boundary conditions of the reconsolidation process are not fixed and vary as a consequence of the interaction between memory features and reminder characteristics. To modify memory properties, participants received a threatening social protocol that improves memory acquisition or a control condition (fake, without social interaction) prior to learning pairs of meaningless syllables. To determine whether a strong young or old declarative memory undergoes the reconsolidation process, we used an interference task (a second list of pairs of meaningless syllables) to disrupt memory re-stabilization. To assess whether the older memory could be strengthened, we repeated the triggering of reconsolidation. Strong young or old memories modulated by a threatening experience could be interfered during reconsolidation and updated (strengthened) by reconsolidation. Rather than being fixed, boundary conditions vary according to the memory features (strong memory), which indicates the dynamic nature of the reconsolidation process. Our findings demonstrate that it is possible to modify these limits by recruiting the reconsolidation process and making it functionally operative again. This novel scenario opens the possibility to new therapeutically approaches that take into account the reconsolidation process. © 2016 Elsevier Inc. Fil:Bavassi, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Forcato, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v130_n_p202_Fernandez http://hdl.handle.net/20.500.12110/paper_10747427_v130_n_p202_Fernandez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Boundary conditions Declarative memory Reconsolidation Social stress Strengthening Treatment outcome declarative memory human human experiment learning social interaction |
| spellingShingle |
Boundary conditions Declarative memory Reconsolidation Social stress Strengthening Treatment outcome declarative memory human human experiment learning social interaction Bavassi, Mariana Luz Forcato, Cecilia Pedreira, Maria Eugenia The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| topic_facet |
Boundary conditions Declarative memory Reconsolidation Social stress Strengthening Treatment outcome declarative memory human human experiment learning social interaction |
| description |
The reconsolidation process is the mechanism by which the strength and/or content of consolidated memories are updated. This process is triggered by the presentation of a reminder (training cues). It is not always possible to trigger the reconsolidation process. For example, memory age and strength are boundary conditions for the reconsolidation process. Here, we investigated the dynamic changes in these conditions. We propose that the boundary conditions of the reconsolidation process are not fixed and vary as a consequence of the interaction between memory features and reminder characteristics. To modify memory properties, participants received a threatening social protocol that improves memory acquisition or a control condition (fake, without social interaction) prior to learning pairs of meaningless syllables. To determine whether a strong young or old declarative memory undergoes the reconsolidation process, we used an interference task (a second list of pairs of meaningless syllables) to disrupt memory re-stabilization. To assess whether the older memory could be strengthened, we repeated the triggering of reconsolidation. Strong young or old memories modulated by a threatening experience could be interfered during reconsolidation and updated (strengthened) by reconsolidation. Rather than being fixed, boundary conditions vary according to the memory features (strong memory), which indicates the dynamic nature of the reconsolidation process. Our findings demonstrate that it is possible to modify these limits by recruiting the reconsolidation process and making it functionally operative again. This novel scenario opens the possibility to new therapeutically approaches that take into account the reconsolidation process. © 2016 Elsevier Inc. |
| author |
Bavassi, Mariana Luz Forcato, Cecilia Pedreira, Maria Eugenia |
| author_facet |
Bavassi, Mariana Luz Forcato, Cecilia Pedreira, Maria Eugenia |
| author_sort |
Bavassi, Mariana Luz |
| title |
The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| title_short |
The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| title_full |
The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| title_fullStr |
The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| title_full_unstemmed |
The dynamic nature of the reconsolidation process and its boundary conditions: Evidence based on human tests |
| title_sort |
dynamic nature of the reconsolidation process and its boundary conditions: evidence based on human tests |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v130_n_p202_Fernandez http://hdl.handle.net/20.500.12110/paper_10747427_v130_n_p202_Fernandez |
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