Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice
Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-kB), which are present before the neuronal activity induced by training...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v119_n_p10_Zalcman http://hdl.handle.net/20.500.12110/paper_10747427_v119_n_p10_Zalcman |
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paper:paper_10747427_v119_n_p10_Zalcman2023-06-08T16:05:02Z Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice Zalcman, Gisela Patricia Federman, Maria Noel De La Fuente, Veronica Romano, Arturo Gabriel Memory consolidation NF-κB Transcription factors Zif268 complementary DNA immunoglobulin enhancer binding protein messenger RNA oligonucleotide transcription factor transcription factor Zif268 unclassified drug early growth response factor 1 Egr1 protein, mouse immunoglobulin enhancer binding protein animal experiment animal tissue Article controlled study gene expression regulation gene function hippocampus immediate early gene long term memory male memory consolidation mental task mouse nonhuman pattern recognition protein expression recognition task performance transcription regulation Zif268 gene animal gene expression regulation metabolism physiology recognition signal transduction Animals Early Growth Response Protein 1 Gene Expression Regulation Hippocampus Male Mice NF-kappa B Recognition (Psychology) Signal Transduction Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-kB), which are present before the neuronal activity induced by training. It was proposed that the activation of these types of TFs allows a second step in gene regulation by induction of immediate-early genes (IEGs) whose protein products are, in turn, TFs. Between these IEGs, zif268 has been found to play a critical role in long-term memory formation and reprocessing after retrieval. Here we found in mice hippocampus that, on one hand, NF-kB was activated 45. min after training in a novel object recognition (NOR) task and that inhibiting NF-kB immediately after training by intrahippocampal administration of NF-kB Decoy DNA impaired NOR memory consolidation. On the other hand, Zif268 protein expression was induced 45. min after NOR training and the administration of DNA antisense to its mRNA post-training impaired recognition memory. Finally, we found that the inhibition of NF-kB by NF-kB Decoy DNA reduced significantly the training-induced Zif268 increment, indicating that NF-kB is involved in the regulation of Zif268 expression. Thus, the present results support the involvement of NF-kB activity-dependent Zif268 expression in the hippocampus during recognition memory consolidation. © 2015 Elsevier Inc. Fil:Zalcman, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Federman, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de la Fuente, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v119_n_p10_Zalcman http://hdl.handle.net/20.500.12110/paper_10747427_v119_n_p10_Zalcman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Memory consolidation NF-κB Transcription factors Zif268 complementary DNA immunoglobulin enhancer binding protein messenger RNA oligonucleotide transcription factor transcription factor Zif268 unclassified drug early growth response factor 1 Egr1 protein, mouse immunoglobulin enhancer binding protein animal experiment animal tissue Article controlled study gene expression regulation gene function hippocampus immediate early gene long term memory male memory consolidation mental task mouse nonhuman pattern recognition protein expression recognition task performance transcription regulation Zif268 gene animal gene expression regulation metabolism physiology recognition signal transduction Animals Early Growth Response Protein 1 Gene Expression Regulation Hippocampus Male Mice NF-kappa B Recognition (Psychology) Signal Transduction |
| spellingShingle |
Memory consolidation NF-κB Transcription factors Zif268 complementary DNA immunoglobulin enhancer binding protein messenger RNA oligonucleotide transcription factor transcription factor Zif268 unclassified drug early growth response factor 1 Egr1 protein, mouse immunoglobulin enhancer binding protein animal experiment animal tissue Article controlled study gene expression regulation gene function hippocampus immediate early gene long term memory male memory consolidation mental task mouse nonhuman pattern recognition protein expression recognition task performance transcription regulation Zif268 gene animal gene expression regulation metabolism physiology recognition signal transduction Animals Early Growth Response Protein 1 Gene Expression Regulation Hippocampus Male Mice NF-kappa B Recognition (Psychology) Signal Transduction Zalcman, Gisela Patricia Federman, Maria Noel De La Fuente, Veronica Romano, Arturo Gabriel Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| topic_facet |
Memory consolidation NF-κB Transcription factors Zif268 complementary DNA immunoglobulin enhancer binding protein messenger RNA oligonucleotide transcription factor transcription factor Zif268 unclassified drug early growth response factor 1 Egr1 protein, mouse immunoglobulin enhancer binding protein animal experiment animal tissue Article controlled study gene expression regulation gene function hippocampus immediate early gene long term memory male memory consolidation mental task mouse nonhuman pattern recognition protein expression recognition task performance transcription regulation Zif268 gene animal gene expression regulation metabolism physiology recognition signal transduction Animals Early Growth Response Protein 1 Gene Expression Regulation Hippocampus Male Mice NF-kappa B Recognition (Psychology) Signal Transduction |
| description |
Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-kB), which are present before the neuronal activity induced by training. It was proposed that the activation of these types of TFs allows a second step in gene regulation by induction of immediate-early genes (IEGs) whose protein products are, in turn, TFs. Between these IEGs, zif268 has been found to play a critical role in long-term memory formation and reprocessing after retrieval. Here we found in mice hippocampus that, on one hand, NF-kB was activated 45. min after training in a novel object recognition (NOR) task and that inhibiting NF-kB immediately after training by intrahippocampal administration of NF-kB Decoy DNA impaired NOR memory consolidation. On the other hand, Zif268 protein expression was induced 45. min after NOR training and the administration of DNA antisense to its mRNA post-training impaired recognition memory. Finally, we found that the inhibition of NF-kB by NF-kB Decoy DNA reduced significantly the training-induced Zif268 increment, indicating that NF-kB is involved in the regulation of Zif268 expression. Thus, the present results support the involvement of NF-kB activity-dependent Zif268 expression in the hippocampus during recognition memory consolidation. © 2015 Elsevier Inc. |
| author |
Zalcman, Gisela Patricia Federman, Maria Noel De La Fuente, Veronica Romano, Arturo Gabriel |
| author_facet |
Zalcman, Gisela Patricia Federman, Maria Noel De La Fuente, Veronica Romano, Arturo Gabriel |
| author_sort |
Zalcman, Gisela Patricia |
| title |
Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| title_short |
Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| title_full |
Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| title_fullStr |
Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| title_full_unstemmed |
Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice |
| title_sort |
nuclear factor kappa b-dependent zif268 expression in hippocampus is required for recognition memory in mice |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v119_n_p10_Zalcman http://hdl.handle.net/20.500.12110/paper_10747427_v119_n_p10_Zalcman |
| work_keys_str_mv |
AT zalcmangiselapatricia nuclearfactorkappabdependentzif268expressioninhippocampusisrequiredforrecognitionmemoryinmice AT federmanmarianoel nuclearfactorkappabdependentzif268expressioninhippocampusisrequiredforrecognitionmemoryinmice AT delafuenteveronica nuclearfactorkappabdependentzif268expressioninhippocampusisrequiredforrecognitionmemoryinmice AT romanoarturogabriel nuclearfactorkappabdependentzif268expressioninhippocampusisrequiredforrecognitionmemoryinmice |
| _version_ |
1768545475048243200 |