QSAR studies of indoyl aryl sulfides and sulfones as reverse transcriptase inhibitors

The inhibitory HIV reverse transcriptase activity of 172 non-nucleoside indoyl aryl sulfones and sulfides is studied with a QSAR analysis, in order to identify the molecular characteristics influencing the interaction with the reverse transcriptase enzyme. This work increases the available QSAR stud...

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Detalles Bibliográficos
Publicado:	2018
Materias:	CORAL HIV reverse transcriptase inhibitors Indoyl aryl sulfides and sulfones PaDEL QSAR indoyl aryl sulfide indoyl aryl sulfone RNA directed DNA polymerase inhibitor sulfone derivative unclassified drug Article cell differentiation conformation controlled study EC50 enzyme activity human Human immunodeficiency virus 1 hydrogen bond in vitro study physical chemistry quantitative structure activity relation T lymphocyte validation process
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10542523_v27_n2_p420_Duchowicz http://hdl.handle.net/20.500.12110/paper_10542523_v27_n2_p420_Duchowicz
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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