Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides

The emergence of multidrug resistance cell lines is one of the major obstacles in the success of cancer chemotherapeutic treatment. Therefore, it remains a big challenge the development of new and effective drugs to defeat cancer. The presence of nitrogen heterocycles in the architectural design of...

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Guardado en:
Detalles Bibliográficos
Publicado: 2017
Materias:
1,2,4-Oxadiazole
1,2,4-Triazole
5-Amino-1,3,4-thiadiazole
Antiproliferative activity
D-Ribose
(5 aryl oxadiazole 3 yl) methyl dextro ribofuranoside derivative
antineoplastic agent
unclassified drug
oxadiazole derivative
ribose
A-549 cell line
antineoplastic activity
antiproliferative activity
apoptosis
Article
cell proliferation
colon cancer cell line
controlled study
drug synthesis
G1 phase cell cycle checkpoint
HeLa cell line
human
human cell
in vitro study
lymphoma cell line
prostate cancer cell line
renal cancer cell line
structure activity relation
analogs and derivatives
chemistry
drug effects
drug screening
synthesis
tumor cell line
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Drug Screening Assays, Antitumor
Humans
Oxadiazoles
Ribose
Structure-Activity Relationship
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v27_n16_p3674_Avanzo
http://hdl.handle.net/20.500.12110/paper_0960894X_v27_n16_p3674_Avanzo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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