Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase

Endothelin stimulates the cells of the zona glomerulosa of the adrenal gland and releases aldosterone. While it is a less potent aldosterone secretagogue than angiotensin II endothelin also potentiates the effects of angiotensin II on aldosterone biosynthesis. Two endothelin receptors have been clon...

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Autores principales:	Pecci, Adali, Cozza, Eduardo Néstor
Publicado:	1994
Materias:	adenosine triphosphatase (potassium sodium) aldosterone cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin receptor endothelin receptor antagonist ouabain sarafotoxin aldosterone release animal cell animal experiment article blood pressure controlled study gene expression molecular cloning nonhuman rat zona glomerulosa Aldosterone Animal Aorta Blood Pressure Cloning, Molecular Endothelins Na(+)-K(+)-Exchanging ATPase Ouabain Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Endothelin Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Strophanthus gratus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v50_n1-2_p49_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v50_n1-2_p49_Pecci
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09600760_v50_n1-2_p49_Pecci
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spelling	paper:paper_09600760_v50_n1-2_p49_Pecci2023-06-08T15:57:23Z Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase Pecci, Adali Cozza, Eduardo Néstor adenosine triphosphatase (potassium sodium) aldosterone cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin receptor endothelin receptor antagonist ouabain sarafotoxin aldosterone release animal cell animal experiment article blood pressure controlled study gene expression molecular cloning nonhuman rat zona glomerulosa Aldosterone Animal Aorta Blood Pressure Cloning, Molecular Endothelins Na(+)-K(+)-Exchanging ATPase Ouabain Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Endothelin Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Strophanthus gratus Endothelin stimulates the cells of the zona glomerulosa of the adrenal gland and releases aldosterone. While it is a less potent aldosterone secretagogue than angiotensin II endothelin also potentiates the effects of angiotensin II on aldosterone biosynthesis. Two endothelin receptors have been cloned and are expressed in the adrenal zona glomerulosa. Intravenous infusion of endothelin at a rate of 80 ng/kg/min for 30 min into rats produced increases in blood pressure, adrenal content of aldosterone and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, but not in the zona fasciculata, of the adrenal. The simultaneous infusion of the isopeptide specific endothelin receptor A (ETA) antagonist BQ-123 blocked the pressor effects of endothelin, but did not alter the increase in aldosterone content of the zona glomerulosa or the ouabain-sensitive sodium potassium ATPase activity. Infusion of Sarafotoxin 6b, an ETB agonist, also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, further indicating that the effect of endothelin is probably mediated by ETB or isopeptide non-specific endothelin receptor. The mechanism by which endothelin stimulates the sodium potassium ATPase is unclear as is the relation between a stimulated sodium potassium ATPase and the potentiation of angiotensin II effect on the adrenal. © 1994. Fil:Pecci, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v50_n1-2_p49_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v50_n1-2_p49_Pecci
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adenosine triphosphatase (potassium sodium) aldosterone cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin receptor endothelin receptor antagonist ouabain sarafotoxin aldosterone release animal cell animal experiment article blood pressure controlled study gene expression molecular cloning nonhuman rat zona glomerulosa Aldosterone Animal Aorta Blood Pressure Cloning, Molecular Endothelins Na(+)-K(+)-Exchanging ATPase Ouabain Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Endothelin Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Strophanthus gratus
spellingShingle	adenosine triphosphatase (potassium sodium) aldosterone cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin receptor endothelin receptor antagonist ouabain sarafotoxin aldosterone release animal cell animal experiment article blood pressure controlled study gene expression molecular cloning nonhuman rat zona glomerulosa Aldosterone Animal Aorta Blood Pressure Cloning, Molecular Endothelins Na(+)-K(+)-Exchanging ATPase Ouabain Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Endothelin Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Strophanthus gratus Pecci, Adali Cozza, Eduardo Néstor Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
topic_facet	adenosine triphosphatase (potassium sodium) aldosterone cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin receptor endothelin receptor antagonist ouabain sarafotoxin aldosterone release animal cell animal experiment article blood pressure controlled study gene expression molecular cloning nonhuman rat zona glomerulosa Aldosterone Animal Aorta Blood Pressure Cloning, Molecular Endothelins Na(+)-K(+)-Exchanging ATPase Ouabain Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptors, Endothelin Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Strophanthus gratus
description	Endothelin stimulates the cells of the zona glomerulosa of the adrenal gland and releases aldosterone. While it is a less potent aldosterone secretagogue than angiotensin II endothelin also potentiates the effects of angiotensin II on aldosterone biosynthesis. Two endothelin receptors have been cloned and are expressed in the adrenal zona glomerulosa. Intravenous infusion of endothelin at a rate of 80 ng/kg/min for 30 min into rats produced increases in blood pressure, adrenal content of aldosterone and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, but not in the zona fasciculata, of the adrenal. The simultaneous infusion of the isopeptide specific endothelin receptor A (ETA) antagonist BQ-123 blocked the pressor effects of endothelin, but did not alter the increase in aldosterone content of the zona glomerulosa or the ouabain-sensitive sodium potassium ATPase activity. Infusion of Sarafotoxin 6b, an ETB agonist, also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, further indicating that the effect of endothelin is probably mediated by ETB or isopeptide non-specific endothelin receptor. The mechanism by which endothelin stimulates the sodium potassium ATPase is unclear as is the relation between a stimulated sodium potassium ATPase and the potentiation of angiotensin II effect on the adrenal. © 1994.
author	Pecci, Adali Cozza, Eduardo Néstor
author_facet	Pecci, Adali Cozza, Eduardo Néstor
author_sort	Pecci, Adali
title	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
title_short	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
title_full	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
title_fullStr	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
title_full_unstemmed	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase
title_sort	endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-atpase
publishDate	1994
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v50_n1-2_p49_Pecci http://hdl.handle.net/20.500.12110/paper_09600760_v50_n1-2_p49_Pecci
work_keys_str_mv	AT pecciadali endothelin1stimulationofaldosteroneandzonaglomerulosaouabainsensitivesodiumpotassiumatpase AT cozzaeduardonestor endothelin1stimulationofaldosteroneandzonaglomerulosaouabainsensitivesodiumpotassiumatpase
_version_	1768545657193234432

Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase

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