Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor

Neurosteroids are the principal endogenous modulators of the γ-Aminobutyric acid receptors (GABAARs), pentameric membrane-bound proteins that can be assembled from at least 19 subunits. In the most abundant GABAAR arrangement (α1β2γ2), neurosteroids can potentiate the GABA action as well as produce...

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Detalles Bibliográficos
Publicado:	2018
Materias:	Activation Binding sites Docking, molecular dynamics simulation GABAA receptors Neurosteroids Potentiation α1β2γ2 heteropentamer 4 aminobutyric acid A receptor alpha1 4 aminobutyric acid A receptor beta2 4 aminobutyric acid A receptor gamma2 brexanolone eltanolone neurosteroid Article binding affinity molecular docking molecular dynamics structural homology
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v182_n_p72_Alvarez http://hdl.handle.net/20.500.12110/paper_09600760_v182_n_p72_Alvarez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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