Exploring the molecular basis of neurosteroid binding to the β3 homopentameric GABAA receptor

Neurosteroids are the principal endogenous modulators of GABAA receptors (GABAARs), which are pentameric membrane-bound proteins that regulate the passage of chloride ions from the extracellular to the intracellular compartment. As consequence of their ability to modify inhibitory functions in the b...

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Detalles Bibliográficos
Autor principal: Estrin, Dario Ariel
Publicado: 2015
Materias:
Binding site
GABAA receptor
Neurosteroids
Specific recognition
β3 homopentamers
3alpha hydroxy 5alpha pregnan 20 one
4 aminobutyric acid A receptor
beta3 homopentameric 4 aminobutyric acid A receptor
eltanolone
neurosteroid
protein
transmembrane domain 1 protein
transmembrane domain 3 protein
transmembrane domain 4 protein
unclassified drug
agents interacting with transmitter, hormone or drug receptors
protein binding
algorithm
Article
binding affinity
binding site
crystal structure
human
mathematical analysis
mathematical computing
molecular biology
molecular docking
molecular dynamics
molecular interaction
physiological process
protein analysis
structure activity relation
chemistry
metabolism
Molecular Dynamics Simulation
Neurotransmitter Agents
Protein Binding
Receptors, GABA-A
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v154_n_p159_Alvarez
http://hdl.handle.net/20.500.12110/paper_09600760_v154_n_p159_Alvarez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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