Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids
Physiological cell turnover is under the control of a sharp and dynamic balance of different homeostatic mechanisms such as the equilibrium between cell proliferation and cell death. These mechanisms play an important role in maintaining normal tissue function and architecture. It is well known that...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v109_n3-5_p273_Viegas http://hdl.handle.net/20.500.12110/paper_09600760_v109_n3-5_p273_Viegas |
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paper:paper_09600760_v109_n3-5_p273_Viegas2023-06-08T15:57:18Z Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids Hoijman, Esteban Pecci, Adali Apoptosis Bcl-2 family proteins Glucocorticoids cyclic AMP cytokine dexamethasone glucocorticoid protein bcl 2 protein bcl x tumor suppressor protein apoptosis breast epithelium cell proliferation endometrium fibroblast hematopoietic system liver cell macrophage monocyte nonhuman ovary follicle cell protein expression review T lymphocyte Animals Apoptosis Biological Markers Glucocorticoids Humans Organ Specificity Proto-Oncogene Proteins c-bcl-2 Signal Transduction Physiological cell turnover is under the control of a sharp and dynamic balance of different homeostatic mechanisms such as the equilibrium between cell proliferation and cell death. These mechanisms play an important role in maintaining normal tissue function and architecture. It is well known that apoptosis is the prevalent mode of physiological cell loss in most tissues. Steroid hormones like glucocorticoids have been identified as key signals controlling cell turnover by modulating programmed cell death in a tissue- and cell-specific manner. In this sense, several reports have demonstrated that glucocorticoids are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages, and T lymphocytes. In contrast, they protect against apoptotic signals evoked by cytokines, cAMP, tumor suppressors, in glandular cells such as the mammary gland epithelia, endometrium, hepatocytes, ovarian follicular cells, and fibroblasts. Although several studies have provided significant information on hormone-dependent apoptosis in an specific tissue, a clearly defined pathway that mediates cell death in response to glucocorticoids in different cell types is still misunderstood. The scope of this review is held to those mechanisms by which glucocorticoids control apoptosis, emphasizing tissue-specific expression of genes that are involved in the apoptotic pathway. © 2008 Elsevier Ltd. All rights reserved. Fil:Hoijman, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pecci, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v109_n3-5_p273_Viegas http://hdl.handle.net/20.500.12110/paper_09600760_v109_n3-5_p273_Viegas |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Apoptosis Bcl-2 family proteins Glucocorticoids cyclic AMP cytokine dexamethasone glucocorticoid protein bcl 2 protein bcl x tumor suppressor protein apoptosis breast epithelium cell proliferation endometrium fibroblast hematopoietic system liver cell macrophage monocyte nonhuman ovary follicle cell protein expression review T lymphocyte Animals Apoptosis Biological Markers Glucocorticoids Humans Organ Specificity Proto-Oncogene Proteins c-bcl-2 Signal Transduction |
spellingShingle |
Apoptosis Bcl-2 family proteins Glucocorticoids cyclic AMP cytokine dexamethasone glucocorticoid protein bcl 2 protein bcl x tumor suppressor protein apoptosis breast epithelium cell proliferation endometrium fibroblast hematopoietic system liver cell macrophage monocyte nonhuman ovary follicle cell protein expression review T lymphocyte Animals Apoptosis Biological Markers Glucocorticoids Humans Organ Specificity Proto-Oncogene Proteins c-bcl-2 Signal Transduction Hoijman, Esteban Pecci, Adali Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
topic_facet |
Apoptosis Bcl-2 family proteins Glucocorticoids cyclic AMP cytokine dexamethasone glucocorticoid protein bcl 2 protein bcl x tumor suppressor protein apoptosis breast epithelium cell proliferation endometrium fibroblast hematopoietic system liver cell macrophage monocyte nonhuman ovary follicle cell protein expression review T lymphocyte Animals Apoptosis Biological Markers Glucocorticoids Humans Organ Specificity Proto-Oncogene Proteins c-bcl-2 Signal Transduction |
description |
Physiological cell turnover is under the control of a sharp and dynamic balance of different homeostatic mechanisms such as the equilibrium between cell proliferation and cell death. These mechanisms play an important role in maintaining normal tissue function and architecture. It is well known that apoptosis is the prevalent mode of physiological cell loss in most tissues. Steroid hormones like glucocorticoids have been identified as key signals controlling cell turnover by modulating programmed cell death in a tissue- and cell-specific manner. In this sense, several reports have demonstrated that glucocorticoids are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages, and T lymphocytes. In contrast, they protect against apoptotic signals evoked by cytokines, cAMP, tumor suppressors, in glandular cells such as the mammary gland epithelia, endometrium, hepatocytes, ovarian follicular cells, and fibroblasts. Although several studies have provided significant information on hormone-dependent apoptosis in an specific tissue, a clearly defined pathway that mediates cell death in response to glucocorticoids in different cell types is still misunderstood. The scope of this review is held to those mechanisms by which glucocorticoids control apoptosis, emphasizing tissue-specific expression of genes that are involved in the apoptotic pathway. © 2008 Elsevier Ltd. All rights reserved. |
author |
Hoijman, Esteban Pecci, Adali |
author_facet |
Hoijman, Esteban Pecci, Adali |
author_sort |
Hoijman, Esteban |
title |
Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
title_short |
Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
title_full |
Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
title_fullStr |
Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
title_full_unstemmed |
Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
title_sort |
mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids |
publishDate |
2008 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v109_n3-5_p273_Viegas http://hdl.handle.net/20.500.12110/paper_09600760_v109_n3-5_p273_Viegas |
work_keys_str_mv |
AT hoijmanesteban mechanismsinvolvedintissuespecificapopotosisregulatedbyglucocorticoids AT pecciadali mechanismsinvolvedintissuespecificapopotosisregulatedbyglucocorticoids |
_version_ |
1768545795723755520 |