Antiherpetic activity of S1, an algal derived sulphated galactan

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The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/m...

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Autores principales:	Pujol, Carlos Alberto, Errea, María Inés, Matulewicz, María Cristina, Damonte, Elsa Beatriz
Publicado:	1996
Materias:	Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v10_n5_p410_Pujol http://hdl.handle.net/20.500.12110/paper_0951418X_v10_n5_p410_Pujol
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0951418X_v10_n5_p410_Pujol
record_format	dspace
spelling	paper:paper_0951418X_v10_n5_p410_Pujol2023-06-08T15:54:53Z Antiherpetic activity of S1, an algal derived sulphated galactan Pujol, Carlos Alberto Errea, María Inés Matulewicz, María Cristina Damonte, Elsa Beatriz Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v10_n5_p410_Pujol http://hdl.handle.net/20.500.12110/paper_0951418X_v10_n5_p410_Pujol
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1
spellingShingle	Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1 Pujol, Carlos Alberto Errea, María Inés Matulewicz, María Cristina Damonte, Elsa Beatriz Antiherpetic activity of S1, an algal derived sulphated galactan
topic_facet	Herpes simplex virus Natural antiviral Pterocladia capillacea Red seaweed Sulphated polysaccharide Virus attachment antivirus agent galactane sulfate plant extract unclassified drug animal cell antiviral activity article concentration response controlled study cytotoxicity drug mechanism herpes simplex virus 1 herpes simplex virus 2 herpes virus host cell human human cell human cytomegalovirus nonhuman pseudorabies herpetovirus red alga virus adsorption algae Animalia Herpes Herpesviridae herpetovirus Human herpesvirus 1 Human herpesvirus 2 Human herpesvirus 5 Pterocladia Pterocladiella capillacea Rhodophyta Simplexvirus Suid herpesvirus 1
description	The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell.
author	Pujol, Carlos Alberto Errea, María Inés Matulewicz, María Cristina Damonte, Elsa Beatriz
author_facet	Pujol, Carlos Alberto Errea, María Inés Matulewicz, María Cristina Damonte, Elsa Beatriz
author_sort	Pujol, Carlos Alberto
title	Antiherpetic activity of S1, an algal derived sulphated galactan
title_short	Antiherpetic activity of S1, an algal derived sulphated galactan
title_full	Antiherpetic activity of S1, an algal derived sulphated galactan
title_fullStr	Antiherpetic activity of S1, an algal derived sulphated galactan
title_full_unstemmed	Antiherpetic activity of S1, an algal derived sulphated galactan
title_sort	antiherpetic activity of s1, an algal derived sulphated galactan
publishDate	1996
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v10_n5_p410_Pujol http://hdl.handle.net/20.500.12110/paper_0951418X_v10_n5_p410_Pujol
work_keys_str_mv	AT pujolcarlosalberto antiherpeticactivityofs1analgalderivedsulphatedgalactan AT erreamariaines antiherpeticactivityofs1analgalderivedsulphatedgalactan AT matulewiczmariacristina antiherpeticactivityofs1analgalderivedsulphatedgalactan AT damonteelsabeatriz antiherpeticactivityofs1analgalderivedsulphatedgalactan
_version_	1768544557812678656

Antiherpetic activity of S1, an algal derived sulphated galactan

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