Antitumor activity of histamine and clozapine in a mouse experimental model of human melanoma

Background: Functional presence of histamine H4 receptor (H4R) was demonstrated in human melanoma cell lines and biopsies. Objective: The purposes of this work were to investigate signal transduction pathways and biological responses triggered by the activation of H4R in human primary (WM35) and met...

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Detalles Bibliográficos
Publicado:	2013
Materias:	ERK1/2 H4R Histamine Melanoma Proliferation Survival 1 (5 chloro 2 indolylcarbonyl) 4 methylpiperazine 1 [2 (amidinothio)ethyl]guanidine 2 [(aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide broxuridine cell marker clozapine cyclic AMP forskolin histamine histamine agonist histamine H4 receptor histamine receptor mitogen activated protein kinase 1 mitogen activated protein kinase 3 unclassified drug animal experiment animal model animal tissue antineoplastic activity article cancer survival cell line cell proliferation cellular distribution clonogenic assay concentration response controlled study drug screening enzyme phosphorylation histochemistry human human cell IC 50 in vitro study in vivo study intracellular signaling male melanoma melanoma cell metastatic melanoma mitosis index mouse nonhuman primary tumor priority journal protein expression protein induction protein synthesis treatment response tumor growth tumor vascularization tumor volume tumor xenograft H(4)R Animals Cell Line, Tumor Cell Proliferation Clozapine Cyclic AMP Extracellular Signal-Regulated MAP Kinases Humans Male Melanoma, Experimental Mice Mice, Nude Neovascularization, Pathologic Phosphorylation Receptors, G-Protein-Coupled Receptors, Histamine Signal Transduction Xenograft Model Antitumor Assays
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09231811_v72_n3_p252_Massari http://hdl.handle.net/20.500.12110/paper_09231811_v72_n3_p252_Massari
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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