Prevalence of hyperhomocysteinemia in an elderly population

Background: Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carr...

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Autores principales: Quintana, Irene Luisa, Kordich, Lucía Clelia
Publicado: 2002
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08957061_v15_n5_p394_Janson
http://hdl.handle.net/20.500.12110/paper_08957061_v15_n5_p394_Janson
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spelling paper:paper_08957061_v15_n5_p394_Janson2023-06-08T15:48:03Z Prevalence of hyperhomocysteinemia in an elderly population Quintana, Irene Luisa Kordich, Lucía Clelia Elderly people Epidemiologic studies Homocysteine Prevalence folic acid homocysteine aged article female folic acid blood level human hyperhomocysteinemia major clinical study male nutrition prevalence priority journal reference value risk factor statistical analysis vascular disease vitamin blood level Age Distribution Aged Aged, 80 and over Cohort Studies Cross-Sectional Studies Female Folic Acid Homocysteine Humans Hyperhomocysteinemia Male Prevalence Sex Distribution Vitamin B 12 Background: Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic studies of HHcy. Procedure: Previously we described the prevalence of hypertension control in an elder population; now, in an observational cross-sectional simple blind study, total homocysteine (tHcy) concentration was determined in 196 of 400 patients from the original cohort. Results: Mean Hcy concentration was 13.2 μmol/L (95% confidence interval 12.4-14.0; range, 5.0 to 48.9); 15.0 μmol/L for men and 12.3 μmol/L for women. Mean serum folic acid levels were 4.9 ± 3.1 ng/mL (range, 2.0 to 20.0 ng/mL), and vitamin B12 levels were 384.8 ± 314.1 pg/mL (range, 48.0 to 1500.0 pg/mL). Taking into account the reference values established by the Third National Health and Nutrition Examination Survey III study, HHcy was detected in 69.8% of all the subjects evaluated. The study showed that 76.2% of the men and 66.4% of the women had high Hcy levels. Conclusions: The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified. © 2002 American Journal of Hypertension, Ltd. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08957061_v15_n5_p394_Janson http://hdl.handle.net/20.500.12110/paper_08957061_v15_n5_p394_Janson
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Elderly people
Epidemiologic studies
Homocysteine
Prevalence
folic acid
homocysteine
aged
article
female
folic acid blood level
human
hyperhomocysteinemia
major clinical study
male
nutrition
prevalence
priority journal
reference value
risk factor
statistical analysis
vascular disease
vitamin blood level
Age Distribution
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Female
Folic Acid
Homocysteine
Humans
Hyperhomocysteinemia
Male
Prevalence
Sex Distribution
Vitamin B 12
spellingShingle Elderly people
Epidemiologic studies
Homocysteine
Prevalence
folic acid
homocysteine
aged
article
female
folic acid blood level
human
hyperhomocysteinemia
major clinical study
male
nutrition
prevalence
priority journal
reference value
risk factor
statistical analysis
vascular disease
vitamin blood level
Age Distribution
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Female
Folic Acid
Homocysteine
Humans
Hyperhomocysteinemia
Male
Prevalence
Sex Distribution
Vitamin B 12
Quintana, Irene Luisa
Kordich, Lucía Clelia
Prevalence of hyperhomocysteinemia in an elderly population
topic_facet Elderly people
Epidemiologic studies
Homocysteine
Prevalence
folic acid
homocysteine
aged
article
female
folic acid blood level
human
hyperhomocysteinemia
major clinical study
male
nutrition
prevalence
priority journal
reference value
risk factor
statistical analysis
vascular disease
vitamin blood level
Age Distribution
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Female
Folic Acid
Homocysteine
Humans
Hyperhomocysteinemia
Male
Prevalence
Sex Distribution
Vitamin B 12
description Background: Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic studies of HHcy. Procedure: Previously we described the prevalence of hypertension control in an elder population; now, in an observational cross-sectional simple blind study, total homocysteine (tHcy) concentration was determined in 196 of 400 patients from the original cohort. Results: Mean Hcy concentration was 13.2 μmol/L (95% confidence interval 12.4-14.0; range, 5.0 to 48.9); 15.0 μmol/L for men and 12.3 μmol/L for women. Mean serum folic acid levels were 4.9 ± 3.1 ng/mL (range, 2.0 to 20.0 ng/mL), and vitamin B12 levels were 384.8 ± 314.1 pg/mL (range, 48.0 to 1500.0 pg/mL). Taking into account the reference values established by the Third National Health and Nutrition Examination Survey III study, HHcy was detected in 69.8% of all the subjects evaluated. The study showed that 76.2% of the men and 66.4% of the women had high Hcy levels. Conclusions: The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified. © 2002 American Journal of Hypertension, Ltd.
author Quintana, Irene Luisa
Kordich, Lucía Clelia
author_facet Quintana, Irene Luisa
Kordich, Lucía Clelia
author_sort Quintana, Irene Luisa
title Prevalence of hyperhomocysteinemia in an elderly population
title_short Prevalence of hyperhomocysteinemia in an elderly population
title_full Prevalence of hyperhomocysteinemia in an elderly population
title_fullStr Prevalence of hyperhomocysteinemia in an elderly population
title_full_unstemmed Prevalence of hyperhomocysteinemia in an elderly population
title_sort prevalence of hyperhomocysteinemia in an elderly population
publishDate 2002
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08957061_v15_n5_p394_Janson
http://hdl.handle.net/20.500.12110/paper_08957061_v15_n5_p394_Janson
work_keys_str_mv AT quintanaireneluisa prevalenceofhyperhomocysteinemiainanelderlypopulation
AT kordichluciaclelia prevalenceofhyperhomocysteinemiainanelderlypopulation
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