Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms
Chronic stress and depression are widely known to down-regulate the immune system, and several antidepressants can reverse this impairment, with or without effects in normal subjects. Although the central nervous system is undoubtedly involved in these events, some psychotropic drugs can also exert...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08891591_v23_n1_p36_Frick http://hdl.handle.net/20.500.12110/paper_08891591_v23_n1_p36_Frick |
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paper:paper_08891591_v23_n1_p36_Frick2023-06-08T15:47:03Z Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms Antidepressant B cells CD4/CD8 Chronic stress Cytokines Depression Fluoxetine Natural killer T cells concanavalin A fluoxetine gamma interferon interleukin 2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue article CD4 CD8 ratio cell proliferation cellular immunity chronic stress controlled study depression drug mechanism female in vitro study nonhuman priority journal T lymphocyte Animals Antidepressive Agents, Second-Generation B-Lymphocytes CD4-CD8 Ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Proliferation Chronic Disease Female Flow Cytometry Fluoxetine Interferon-gamma Interleukin-2 Killer Cells, Natural Mice Mice, Inbred BALB C Restraint, Physical Reverse Transcriptase Polymerase Chain Reaction Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha Chronic stress and depression are widely known to down-regulate the immune system, and several antidepressants can reverse this impairment, with or without effects in normal subjects. Although the central nervous system is undoubtedly involved in these events, some psychotropic drugs can also exert direct effects on lymphoid cells. We have recently shown that the antidepressant fluoxetine enhances T cell proliferation and TH1 cytokine production in vivo, without changes on CD4/CD8 subsets. In vitro, a direct action of fluoxetine upon T lymphocyte reactivity by complex mechanisms was also described. In another work, we also found that chronic stress reduces T cell mediated immunity, namely a decrease of T cell response to mitogens, TH1 cytokine production and CD4+-but not CD8+-T lymphocytes. Here we investigated the effects of fluoxetine on chronic stress-driven immune system depression. We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-γ and tumor necrosis factor-α production by compensatory mechanisms. In addition, CD4/CD8 ratio was also normalized by antidepressant administration, but this seems to be a non-compensatory effect associated specifically to stress. No changes were observed in other lymphoid cells, i.e. natural killer cells and B lymphocytes. Finally, we observed that fluoxetine is able to reverse T cell reactivity impairment in vitro by a direct action at clinically relevant doses. These results highlight the relevance of pharmacological treatment of stress and depression, and may help to begin elucidating the complex events triggered-directly and/or indirectly-by antidepressants in non-neuronal cell types. © 2008 Elsevier Inc. All rights reserved. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08891591_v23_n1_p36_Frick http://hdl.handle.net/20.500.12110/paper_08891591_v23_n1_p36_Frick |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antidepressant B cells CD4/CD8 Chronic stress Cytokines Depression Fluoxetine Natural killer T cells concanavalin A fluoxetine gamma interferon interleukin 2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue article CD4 CD8 ratio cell proliferation cellular immunity chronic stress controlled study depression drug mechanism female in vitro study nonhuman priority journal T lymphocyte Animals Antidepressive Agents, Second-Generation B-Lymphocytes CD4-CD8 Ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Proliferation Chronic Disease Female Flow Cytometry Fluoxetine Interferon-gamma Interleukin-2 Killer Cells, Natural Mice Mice, Inbred BALB C Restraint, Physical Reverse Transcriptase Polymerase Chain Reaction Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha |
| spellingShingle |
Antidepressant B cells CD4/CD8 Chronic stress Cytokines Depression Fluoxetine Natural killer T cells concanavalin A fluoxetine gamma interferon interleukin 2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue article CD4 CD8 ratio cell proliferation cellular immunity chronic stress controlled study depression drug mechanism female in vitro study nonhuman priority journal T lymphocyte Animals Antidepressive Agents, Second-Generation B-Lymphocytes CD4-CD8 Ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Proliferation Chronic Disease Female Flow Cytometry Fluoxetine Interferon-gamma Interleukin-2 Killer Cells, Natural Mice Mice, Inbred BALB C Restraint, Physical Reverse Transcriptase Polymerase Chain Reaction Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| topic_facet |
Antidepressant B cells CD4/CD8 Chronic stress Cytokines Depression Fluoxetine Natural killer T cells concanavalin A fluoxetine gamma interferon interleukin 2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue article CD4 CD8 ratio cell proliferation cellular immunity chronic stress controlled study depression drug mechanism female in vitro study nonhuman priority journal T lymphocyte Animals Antidepressive Agents, Second-Generation B-Lymphocytes CD4-CD8 Ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cell Proliferation Chronic Disease Female Flow Cytometry Fluoxetine Interferon-gamma Interleukin-2 Killer Cells, Natural Mice Mice, Inbred BALB C Restraint, Physical Reverse Transcriptase Polymerase Chain Reaction Stress, Psychological T-Lymphocytes Tumor Necrosis Factor-alpha |
| description |
Chronic stress and depression are widely known to down-regulate the immune system, and several antidepressants can reverse this impairment, with or without effects in normal subjects. Although the central nervous system is undoubtedly involved in these events, some psychotropic drugs can also exert direct effects on lymphoid cells. We have recently shown that the antidepressant fluoxetine enhances T cell proliferation and TH1 cytokine production in vivo, without changes on CD4/CD8 subsets. In vitro, a direct action of fluoxetine upon T lymphocyte reactivity by complex mechanisms was also described. In another work, we also found that chronic stress reduces T cell mediated immunity, namely a decrease of T cell response to mitogens, TH1 cytokine production and CD4+-but not CD8+-T lymphocytes. Here we investigated the effects of fluoxetine on chronic stress-driven immune system depression. We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-γ and tumor necrosis factor-α production by compensatory mechanisms. In addition, CD4/CD8 ratio was also normalized by antidepressant administration, but this seems to be a non-compensatory effect associated specifically to stress. No changes were observed in other lymphoid cells, i.e. natural killer cells and B lymphocytes. Finally, we observed that fluoxetine is able to reverse T cell reactivity impairment in vitro by a direct action at clinically relevant doses. These results highlight the relevance of pharmacological treatment of stress and depression, and may help to begin elucidating the complex events triggered-directly and/or indirectly-by antidepressants in non-neuronal cell types. © 2008 Elsevier Inc. All rights reserved. |
| title |
Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| title_short |
Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| title_full |
Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| title_fullStr |
Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| title_full_unstemmed |
Fluoxetine directly counteracts the adverse effects of chronic stress on T cell immunity by compensatory and specific mechanisms |
| title_sort |
fluoxetine directly counteracts the adverse effects of chronic stress on t cell immunity by compensatory and specific mechanisms |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08891591_v23_n1_p36_Frick http://hdl.handle.net/20.500.12110/paper_08891591_v23_n1_p36_Frick |
| _version_ |
1768544508433137664 |