Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

Galectins (Gals) have emerged as potent immunoregulatory molecules that control chronic inflammation through distinct mechanisms. Gal-8, a tandem-repeat type Gal with unique preference for α2,3-sialylated glycans, is ubiquitously expressed, but little is known about its role in T-cell differentiatio...

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Publicado:	2016
Materias:	cytotoxic T lymphocyte antigen 4 galectin 8 gamma interferon interleukin 10 interleukin 17 interleukin 2 interleukin 2 receptor beta interleukin 4 Smad3 protein STAT5 protein transcription factor FOXP3 transforming growth factor beta transforming growth factor beta receptor 2 galectin galectin-8, mouse interleukin 2 receptor animal cell antiproliferative activity Article CD4+ T lymphocyte controlled study cytokine production in vitro study lymphocyte differentiation lymphocyte proliferation mouse nonhuman protein function regulatory T lymphocyte signal transduction animal C57BL mouse cell culture cell differentiation immunology lymphocyte activation metabolism Animals Cell Differentiation Cells, Cultured CTLA-4 Antigen Galectins Interleukin-10 Interleukin-2 Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Interleukin-2 Signal Transduction T-Lymphocytes, Regulatory Transforming Growth Factor beta
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v94_n2_p213_Sampson http://hdl.handle.net/20.500.12110/paper_08189641_v94_n2_p213_Sampson
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_08189641_v94_n2_p213_Sampson
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spelling	paper:paper_08189641_v94_n2_p213_Sampson2025-07-30T18:22:27Z Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling cytotoxic T lymphocyte antigen 4 galectin 8 gamma interferon interleukin 10 interleukin 17 interleukin 2 interleukin 2 receptor beta interleukin 4 Smad3 protein STAT5 protein transcription factor FOXP3 transforming growth factor beta transforming growth factor beta receptor 2 cytotoxic T lymphocyte antigen 4 galectin galectin-8, mouse interleukin 10 interleukin 2 interleukin 2 receptor transforming growth factor beta animal cell antiproliferative activity Article CD4+ T lymphocyte controlled study cytokine production in vitro study lymphocyte differentiation lymphocyte proliferation mouse nonhuman protein function regulatory T lymphocyte signal transduction animal C57BL mouse cell culture cell differentiation immunology lymphocyte activation metabolism regulatory T lymphocyte Animals Cell Differentiation Cells, Cultured CTLA-4 Antigen Galectins Interleukin-10 Interleukin-2 Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Interleukin-2 Signal Transduction T-Lymphocytes, Regulatory Transforming Growth Factor beta Galectins (Gals) have emerged as potent immunoregulatory molecules that control chronic inflammation through distinct mechanisms. Gal-8, a tandem-repeat type Gal with unique preference for α2,3-sialylated glycans, is ubiquitously expressed, but little is known about its role in T-cell differentiation. Here we report that Gal-8 promotes the polyclonal differentiation of primary mouse regulatory T (Treg) cells in vitro. We further show that Gal-8 also facilitates antigen-specific differentiation of Treg cells, and that Treg cells polarized in the presence of Gal-8 express cytotoxic T-lymphocyte antigen-4 and interleukin (IL)-10 at a higher frequency than control Treg cells, and efficiently inhibit proliferation of activated T-cells in vitro. Investigation of the mechanism by which Gal-8 promotes Treg conversion revealed that Gal-8 activates transforming growth factor-β signaling and promotes sustained IL-2R signaling. Taken together, these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases. © 2016 Australasian Society for Immunology Inc. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v94_n2_p213_Sampson http://hdl.handle.net/20.500.12110/paper_08189641_v94_n2_p213_Sampson
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cytotoxic T lymphocyte antigen 4 galectin 8 gamma interferon interleukin 10 interleukin 17 interleukin 2 interleukin 2 receptor beta interleukin 4 Smad3 protein STAT5 protein transcription factor FOXP3 transforming growth factor beta transforming growth factor beta receptor 2 cytotoxic T lymphocyte antigen 4 galectin galectin-8, mouse interleukin 10 interleukin 2 interleukin 2 receptor transforming growth factor beta animal cell antiproliferative activity Article CD4+ T lymphocyte controlled study cytokine production in vitro study lymphocyte differentiation lymphocyte proliferation mouse nonhuman protein function regulatory T lymphocyte signal transduction animal C57BL mouse cell culture cell differentiation immunology lymphocyte activation metabolism regulatory T lymphocyte Animals Cell Differentiation Cells, Cultured CTLA-4 Antigen Galectins Interleukin-10 Interleukin-2 Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Interleukin-2 Signal Transduction T-Lymphocytes, Regulatory Transforming Growth Factor beta
spellingShingle	cytotoxic T lymphocyte antigen 4 galectin 8 gamma interferon interleukin 10 interleukin 17 interleukin 2 interleukin 2 receptor beta interleukin 4 Smad3 protein STAT5 protein transcription factor FOXP3 transforming growth factor beta transforming growth factor beta receptor 2 cytotoxic T lymphocyte antigen 4 galectin galectin-8, mouse interleukin 10 interleukin 2 interleukin 2 receptor transforming growth factor beta animal cell antiproliferative activity Article CD4+ T lymphocyte controlled study cytokine production in vitro study lymphocyte differentiation lymphocyte proliferation mouse nonhuman protein function regulatory T lymphocyte signal transduction animal C57BL mouse cell culture cell differentiation immunology lymphocyte activation metabolism regulatory T lymphocyte Animals Cell Differentiation Cells, Cultured CTLA-4 Antigen Galectins Interleukin-10 Interleukin-2 Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Interleukin-2 Signal Transduction T-Lymphocytes, Regulatory Transforming Growth Factor beta Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
topic_facet	cytotoxic T lymphocyte antigen 4 galectin 8 gamma interferon interleukin 10 interleukin 17 interleukin 2 interleukin 2 receptor beta interleukin 4 Smad3 protein STAT5 protein transcription factor FOXP3 transforming growth factor beta transforming growth factor beta receptor 2 cytotoxic T lymphocyte antigen 4 galectin galectin-8, mouse interleukin 10 interleukin 2 interleukin 2 receptor transforming growth factor beta animal cell antiproliferative activity Article CD4+ T lymphocyte controlled study cytokine production in vitro study lymphocyte differentiation lymphocyte proliferation mouse nonhuman protein function regulatory T lymphocyte signal transduction animal C57BL mouse cell culture cell differentiation immunology lymphocyte activation metabolism regulatory T lymphocyte Animals Cell Differentiation Cells, Cultured CTLA-4 Antigen Galectins Interleukin-10 Interleukin-2 Lymphocyte Activation Mice Mice, Inbred C57BL Receptors, Interleukin-2 Signal Transduction T-Lymphocytes, Regulatory Transforming Growth Factor beta
description	Galectins (Gals) have emerged as potent immunoregulatory molecules that control chronic inflammation through distinct mechanisms. Gal-8, a tandem-repeat type Gal with unique preference for α2,3-sialylated glycans, is ubiquitously expressed, but little is known about its role in T-cell differentiation. Here we report that Gal-8 promotes the polyclonal differentiation of primary mouse regulatory T (Treg) cells in vitro. We further show that Gal-8 also facilitates antigen-specific differentiation of Treg cells, and that Treg cells polarized in the presence of Gal-8 express cytotoxic T-lymphocyte antigen-4 and interleukin (IL)-10 at a higher frequency than control Treg cells, and efficiently inhibit proliferation of activated T-cells in vitro. Investigation of the mechanism by which Gal-8 promotes Treg conversion revealed that Gal-8 activates transforming growth factor-β signaling and promotes sustained IL-2R signaling. Taken together, these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases. © 2016 Australasian Society for Immunology Inc.
title	Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
title_short	Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
title_full	Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
title_fullStr	Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
title_full_unstemmed	Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
title_sort	galectin-8 promotes regulatory t-cell differentiation by modulating il-2 and tgfβ signaling
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v94_n2_p213_Sampson http://hdl.handle.net/20.500.12110/paper_08189641_v94_n2_p213_Sampson
_version_	1840325815671193600

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

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