Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes
Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and...
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1994
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357907_v12_n4_p390_Chasseing http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing |
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paper:paper_07357907_v12_n4_p390_Chasseing2023-06-08T15:44:08Z Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes escherichia coli lipopolysaccharide interleukin 1 prostaglandin e2 animal cell animal experiment animal model antigen antibody complex article cancer growth carcinogenesis controlled study female host resistance immunomodulation mononuclear cell mouse nonhuman priority journal sarcoma cell tumor immunity Animal Antigen-Antibody Complex Cell Adhesion Cell Division Dinoprostone Escherichia coli Evaluation Studies Female Interleukin-1 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred C3H Monocytes Neoplasm Transplantation Sarcoma 180 Spleen Support, Non-U.S. Gov't Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357907_v12_n4_p390_Chasseing http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
escherichia coli lipopolysaccharide interleukin 1 prostaglandin e2 animal cell animal experiment animal model antigen antibody complex article cancer growth carcinogenesis controlled study female host resistance immunomodulation mononuclear cell mouse nonhuman priority journal sarcoma cell tumor immunity Animal Antigen-Antibody Complex Cell Adhesion Cell Division Dinoprostone Escherichia coli Evaluation Studies Female Interleukin-1 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred C3H Monocytes Neoplasm Transplantation Sarcoma 180 Spleen Support, Non-U.S. Gov't |
spellingShingle |
escherichia coli lipopolysaccharide interleukin 1 prostaglandin e2 animal cell animal experiment animal model antigen antibody complex article cancer growth carcinogenesis controlled study female host resistance immunomodulation mononuclear cell mouse nonhuman priority journal sarcoma cell tumor immunity Animal Antigen-Antibody Complex Cell Adhesion Cell Division Dinoprostone Escherichia coli Evaluation Studies Female Interleukin-1 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred C3H Monocytes Neoplasm Transplantation Sarcoma 180 Spleen Support, Non-U.S. Gov't Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
topic_facet |
escherichia coli lipopolysaccharide interleukin 1 prostaglandin e2 animal cell animal experiment animal model antigen antibody complex article cancer growth carcinogenesis controlled study female host resistance immunomodulation mononuclear cell mouse nonhuman priority journal sarcoma cell tumor immunity Animal Antigen-Antibody Complex Cell Adhesion Cell Division Dinoprostone Escherichia coli Evaluation Studies Female Interleukin-1 Lipopolysaccharides Mice Mice, Inbred BALB C Mice, Inbred C3H Monocytes Neoplasm Transplantation Sarcoma 180 Spleen Support, Non-U.S. Gov't |
description |
Cultured splenic mononuclear adherent cells (SMAc) from normal BALB/c mice as well as those from mice bearing 10-day sarcoma 180 (S180), exhibited a marked increase in Escherichia coli lipopolysaccharide-stimulated interleukin-1 (IL-1) production, when compared to spontaneous values. On days 20 and 30 following S180 challenge, a decrease in this effect on IL-1 production in treated and untreated SMAc was observed. Concomitantly with the alterations in the regulation of IL-1 production during tumor growth, an increase in the levels of prostaglandin E2 and serum immune complexes could be detected. These data suggest that the immunosuppression associated with later stages of tumor development may be due to direct effects on monocytes, by means of a down-regulation of IL-1 production. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
title |
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
title_short |
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
title_full |
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
title_fullStr |
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
title_full_unstemmed |
Effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
title_sort |
effects of sarcoma 180 growth on interleukin-1 and circulating immune complexes |
publishDate |
1994 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357907_v12_n4_p390_Chasseing http://hdl.handle.net/20.500.12110/paper_07357907_v12_n4_p390_Chasseing |
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1768545697196408832 |