The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients

Small molecules targeting kinases involved in B cell receptor signaling are showing encouraging clinical activity in chronic lymphocytic leukemia (CLL) patients. Fostamatinib (R406) and entospletinib (GS-9973) are ATP-competitive inhibitors designed to target spleen tyrosine kinase (Syk) that have s...

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Detalles Bibliográficos
Autores principales:	Almejún, María Belén, Giordano, Mirta Nilda, Gamberale, Romina, Borge, Mercedes
Publicado:	2017
Materias:	BCR-associated kinase inhibitors Chronic lymphocytic leukemia GS-9973 R406 Syk inhibitors CD40 ligand chemokine receptor CCR7 chemokine receptor CXCR4 entospletinib fostamatinib gamma interferon interleukin 10 interleukin 4 protein kinase Syk protein kinase ZAP 70 rituximab 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo(1,2-a)pyrazin-8-amine indazole derivative lymphocyte antigen receptor N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine oxazine derivative pyrazine derivative pyridine derivative antineoplastic activity Article cancer patient CD4+ T lymphocyte cell migration chronic lymphatic leukemia controlled study cytokine release human human cell lymphocyte activation lymphocyte function lymphocyte proliferation macrophage phagocytosis priority journal protein phosphorylation upregulation aged antagonists and inhibitors cell culture cell proliferation drug effects female immunology Leukemia, Lymphocytic, Chronic, B-Cell male metabolism middle aged phosphorylation T lymphocyte very elderly Aged Aged, 80 and over Cell Proliferation Cells, Cultured Female Humans Indazoles Lymphocyte Activation Macrophages Male Middle Aged Oxazines Phagocytosis Phosphorylation Pyrazines Pyridines Receptors, Antigen, T-Cell Rituximab Syk Kinase T-Lymphocytes ZAP-70 Protein-Tyrosine Kinase
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407004_v66_n4_p461_Colado http://hdl.handle.net/20.500.12110/paper_03407004_v66_n4_p461_Colado
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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