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spelling paper:paper_03406245_v77_n6_p1090_Duboscq2023-06-08T15:34:08Z Plasminogen: An important hemostatic parameter in septic patients Duboscq, Cristina Quintana, Irene Luisa Sassetti, Beatriz Kordich, Lucía Clelia alpha 2 antiplasmin antiplasmin antithrombin elastase alpha 1 protease inhibitor elastase inhibitor plasminogen plasminogen activator inhibitor thrombin unclassified drug adult aged article blood clotting controlled study enzyme activity fibrinolysis hemostasis human immunoblotting intensive care major clinical study priority journal prognosis protein blood level protein degradation sepsis septicemia Adult Aged Antiplasmin Hemostasis Humans Middle Aged Plasminogen Prognosis Prospective Studies Sepsis Background: Previously we observed in some but not all septic patients a low plasma concentration of plasminogen. Objectives: To investigate prospectively whether plasma levels of plasminogen or the ratio of plasminogen to alpha-2-antiplasmin have a prognostic value for survival from sepsis and to study the variation of other hemostatic parameters during septicemia. Patients: The study population consisted of 45 consecutive patients with septicemia, 15 non-septic patients from the same intensive care unit and 30 healthy volunteers. Measurements and Main Results: Plasminogen concentrations were significantly lower (p < 0.001) in plasma of septic patients (median 0,62 IU/ml range: 0.15-1,06) than in plasma of healthy controls (median 1.00 IU/ml, range: 0.75-1.10) or of non-septic intensive care patients (median 1.00 IU/ml, range: 0.82-1.08). Among the other parameters tested, plasminogen activator inhibitor (PAI-1) antigen concentration and PAI activity were similar in septic and non-septic intensive care patients, but higher than in healthy controls. Concentrations of elastase-alpha-1-protease inhibitor or of thrombin-antithrombin complexes were higher in septic patients than in non-septic intensive care patients or healthy controls. A degraded form of plasminogen of 38 kDa was detected by Western blot analysis in the plasma of septic patients, but not in plasma of non-septic intensive care patients or controls. Plasminogen alone or the ratio of plasminogen to antiplasmin were good markers for survival from septicemia. E.g. for plasminogen at a cut off of 0.65 IU/ml, sensitivity was 90.5% and specificity 66.7%, whereas for the ratio of plasminogen over antiplasmin at a cut off ratio of 0,65 IU/ml, sensitivity was 95.2% and specificity 70.8%. Conclusion: Plasminogen or the ratio of plasminogen to antiplasmin are sensitive markers for survival in patients with septicemia. Fil:Duboscq, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sassetti, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq http://hdl.handle.net/20.500.12110/paper_03406245_v77_n6_p1090_Duboscq
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic alpha 2 antiplasmin
antiplasmin
antithrombin
elastase alpha 1 protease inhibitor
elastase inhibitor
plasminogen
plasminogen activator inhibitor
thrombin
unclassified drug
adult
aged
article
blood clotting
controlled study
enzyme activity
fibrinolysis
hemostasis
human
immunoblotting
intensive care
major clinical study
priority journal
prognosis
protein blood level
protein degradation
sepsis
septicemia
Adult
Aged
Antiplasmin
Hemostasis
Humans
Middle Aged
Plasminogen
Prognosis
Prospective Studies
Sepsis
spellingShingle alpha 2 antiplasmin
antiplasmin
antithrombin
elastase alpha 1 protease inhibitor
elastase inhibitor
plasminogen
plasminogen activator inhibitor
thrombin
unclassified drug
adult
aged
article
blood clotting
controlled study
enzyme activity
fibrinolysis
hemostasis
human
immunoblotting
intensive care
major clinical study
priority journal
prognosis
protein blood level
protein degradation
sepsis
septicemia
Adult
Aged
Antiplasmin
Hemostasis
Humans
Middle Aged
Plasminogen
Prognosis
Prospective Studies
Sepsis
Duboscq, Cristina
Quintana, Irene Luisa
Sassetti, Beatriz
Kordich, Lucía Clelia
Plasminogen: An important hemostatic parameter in septic patients
topic_facet alpha 2 antiplasmin
antiplasmin
antithrombin
elastase alpha 1 protease inhibitor
elastase inhibitor
plasminogen
plasminogen activator inhibitor
thrombin
unclassified drug
adult
aged
article
blood clotting
controlled study
enzyme activity
fibrinolysis
hemostasis
human
immunoblotting
intensive care
major clinical study
priority journal
prognosis
protein blood level
protein degradation
sepsis
septicemia
Adult
Aged
Antiplasmin
Hemostasis
Humans
Middle Aged
Plasminogen
Prognosis
Prospective Studies
Sepsis
description Background: Previously we observed in some but not all septic patients a low plasma concentration of plasminogen. Objectives: To investigate prospectively whether plasma levels of plasminogen or the ratio of plasminogen to alpha-2-antiplasmin have a prognostic value for survival from sepsis and to study the variation of other hemostatic parameters during septicemia. Patients: The study population consisted of 45 consecutive patients with septicemia, 15 non-septic patients from the same intensive care unit and 30 healthy volunteers. Measurements and Main Results: Plasminogen concentrations were significantly lower (p < 0.001) in plasma of septic patients (median 0,62 IU/ml range: 0.15-1,06) than in plasma of healthy controls (median 1.00 IU/ml, range: 0.75-1.10) or of non-septic intensive care patients (median 1.00 IU/ml, range: 0.82-1.08). Among the other parameters tested, plasminogen activator inhibitor (PAI-1) antigen concentration and PAI activity were similar in septic and non-septic intensive care patients, but higher than in healthy controls. Concentrations of elastase-alpha-1-protease inhibitor or of thrombin-antithrombin complexes were higher in septic patients than in non-septic intensive care patients or healthy controls. A degraded form of plasminogen of 38 kDa was detected by Western blot analysis in the plasma of septic patients, but not in plasma of non-septic intensive care patients or controls. Plasminogen alone or the ratio of plasminogen to antiplasmin were good markers for survival from septicemia. E.g. for plasminogen at a cut off of 0.65 IU/ml, sensitivity was 90.5% and specificity 66.7%, whereas for the ratio of plasminogen over antiplasmin at a cut off ratio of 0,65 IU/ml, sensitivity was 95.2% and specificity 70.8%. Conclusion: Plasminogen or the ratio of plasminogen to antiplasmin are sensitive markers for survival in patients with septicemia.
author Duboscq, Cristina
Quintana, Irene Luisa
Sassetti, Beatriz
Kordich, Lucía Clelia
author_facet Duboscq, Cristina
Quintana, Irene Luisa
Sassetti, Beatriz
Kordich, Lucía Clelia
author_sort Duboscq, Cristina
title Plasminogen: An important hemostatic parameter in septic patients
title_short Plasminogen: An important hemostatic parameter in septic patients
title_full Plasminogen: An important hemostatic parameter in septic patients
title_fullStr Plasminogen: An important hemostatic parameter in septic patients
title_full_unstemmed Plasminogen: An important hemostatic parameter in septic patients
title_sort plasminogen: an important hemostatic parameter in septic patients
publishDate 1997
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03406245_v77_n6_p1090_Duboscq
http://hdl.handle.net/20.500.12110/paper_03406245_v77_n6_p1090_Duboscq
work_keys_str_mv AT duboscqcristina plasminogenanimportanthemostaticparameterinsepticpatients
AT quintanaireneluisa plasminogenanimportanthemostaticparameterinsepticpatients
AT sassettibeatriz plasminogenanimportanthemostaticparameterinsepticpatients
AT kordichluciaclelia plasminogenanimportanthemostaticparameterinsepticpatients
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