N-homocysteinylation reactions related to hyperhomocysteinemia

Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocys...

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Detalles Bibliográficos
Autor principal: Quintana, Irene Luisa
Publicado: 2016
Materias:
Homocysteine-thiolactone
Hyperhomocysteinemia
N-homocysteinylation
Occlusive vascular disease
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud
http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03252957_v50_n4_p679_Genoud
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spelling paper:paper_03252957_v50_n4_p679_Genoud2023-06-08T15:32:25Z N-homocysteinylation reactions related to hyperhomocysteinemia Quintana, Irene Luisa Homocysteine-thiolactone Hyperhomocysteinemia N-homocysteinylation Occlusive vascular disease Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocysteinemia. These two species, Hcy and HTL can spontaneously react with proteins, through S and N-homocysteinylation process, respectively. Both reactions produce post-translational protein changes, impairing structural and functional features. In recent years, interest has been developed in HTL and its effects on human health. N-homocysteinylation is the reaction between the carboxyl group of HTL and ϵ-amino group of lysine residues, rendering free sulfhydryl groups able to participate in redox reactions. N-homocysteinylated proteins are prone to misfolding and oxidative damage, inducing cytotoxic and immunogenic effects. Metabolic conversion of Hcy to HTL as well as protein N-homocysteinylation is one of the mechanisms underlying the development of pathologies associated to hyperhomocysteinemia, such as cardiovascular and neurodegenerative diseases. Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Homocysteine-thiolactone
Hyperhomocysteinemia
N-homocysteinylation
Occlusive vascular disease
spellingShingle Homocysteine-thiolactone
Hyperhomocysteinemia
N-homocysteinylation
Occlusive vascular disease
Quintana, Irene Luisa
N-homocysteinylation reactions related to hyperhomocysteinemia
topic_facet Homocysteine-thiolactone
Hyperhomocysteinemia
N-homocysteinylation
Occlusive vascular disease
description Increased plasma homocysteine levels (hyperhomocysteinemia) are associated with occlusive vascular diseases, such as atherosclerosis and thrombosis. Reduced homocysteine (Hcy) and its cyclic ester, homocysteine thiolactone (HTL) would be involved in the detrimental effects associated to hyperhomocysteinemia. These two species, Hcy and HTL can spontaneously react with proteins, through S and N-homocysteinylation process, respectively. Both reactions produce post-translational protein changes, impairing structural and functional features. In recent years, interest has been developed in HTL and its effects on human health. N-homocysteinylation is the reaction between the carboxyl group of HTL and ϵ-amino group of lysine residues, rendering free sulfhydryl groups able to participate in redox reactions. N-homocysteinylated proteins are prone to misfolding and oxidative damage, inducing cytotoxic and immunogenic effects. Metabolic conversion of Hcy to HTL as well as protein N-homocysteinylation is one of the mechanisms underlying the development of pathologies associated to hyperhomocysteinemia, such as cardiovascular and neurodegenerative diseases.
author Quintana, Irene Luisa
author_facet Quintana, Irene Luisa
author_sort Quintana, Irene Luisa
title N-homocysteinylation reactions related to hyperhomocysteinemia
title_short N-homocysteinylation reactions related to hyperhomocysteinemia
title_full N-homocysteinylation reactions related to hyperhomocysteinemia
title_fullStr N-homocysteinylation reactions related to hyperhomocysteinemia
title_full_unstemmed N-homocysteinylation reactions related to hyperhomocysteinemia
title_sort n-homocysteinylation reactions related to hyperhomocysteinemia
publishDate 2016
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v50_n4_p679_Genoud
http://hdl.handle.net/20.500.12110/paper_03252957_v50_n4_p679_Genoud
work_keys_str_mv AT quintanaireneluisa nhomocysteinylationreactionsrelatedtohyperhomocysteinemia
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