Fibrin network variability

Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thromb...

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Detalles Bibliográficos
Autor principal: Lauricella, Ana María
Publicado: 2007
Materias:
Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella
http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03252957_v41_n1_p7_Lauricella
record_format dspace
spelling paper:paper_03252957_v41_n1_p7_Lauricella2023-06-08T15:32:22Z Fibrin network variability Lauricella, Ana María Fibrin Fibrin properties Fibrin-formation Fibrinogen Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thrombin and factor XIII. Greater fibrinogen or thrombin concentrations produce more dense, less porous and shorter fibered-fibrin networks. Fibrinogen alterations can generate abnormal fibrin, with different susceptibility to lysis, while calcium ions increase the fibrin networks' rigidity and porosity. Plasminogen activation and fibrinolysis rate are strongly dependent on the size and the fibrin network architecture. Tight networks are lysed more slowly while, within the same gel, thin fibers are lysed before thick ones. Otherwise, thicker fibers proved to be a better cofactor of plasminogen activation. Taking into account these factors helps understand the different fibrinolytic response, mainly when it is not explained by laboratory studies. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
spellingShingle Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
Lauricella, Ana María
Fibrin network variability
topic_facet Fibrin
Fibrin properties
Fibrin-formation
Fibrinogen
description Fibrin is a protein network present in the clot. It can be characterized by its structure, fibers dimensions, ramification degree, porosity, viscoelasticity and deformability. All these properties depend on temperature, ions concentrations and on other plasmatic substances, mainly fibrinogen, thrombin and factor XIII. Greater fibrinogen or thrombin concentrations produce more dense, less porous and shorter fibered-fibrin networks. Fibrinogen alterations can generate abnormal fibrin, with different susceptibility to lysis, while calcium ions increase the fibrin networks' rigidity and porosity. Plasminogen activation and fibrinolysis rate are strongly dependent on the size and the fibrin network architecture. Tight networks are lysed more slowly while, within the same gel, thin fibers are lysed before thick ones. Otherwise, thicker fibers proved to be a better cofactor of plasminogen activation. Taking into account these factors helps understand the different fibrinolytic response, mainly when it is not explained by laboratory studies.
author Lauricella, Ana María
author_facet Lauricella, Ana María
author_sort Lauricella, Ana María
title Fibrin network variability
title_short Fibrin network variability
title_full Fibrin network variability
title_fullStr Fibrin network variability
title_full_unstemmed Fibrin network variability
title_sort fibrin network variability
publishDate 2007
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v41_n1_p7_Lauricella
http://hdl.handle.net/20.500.12110/paper_03252957_v41_n1_p7_Lauricella
work_keys_str_mv AT lauricellaanamaria fibrinnetworkvariability
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