Effect of sodium citrate concentration on coagulation assays

The aim of this study was to assess the extent of influence of citrate concentration on the results of routine coagulation assays (prothrombin time (PT) and activated partial thromboplastin time (APTT). PT was evaluated using three tromboplastins of different origin and APTT was determined by four d...

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Autores principales:	Duboscq, Cristina, Kordich, Lucía Clelia
Publicado:	2005
Materias:	Activated partial thromboplastin time Prothrombin time Sodium citrate concentration citrate sodium heparin reagent thromboplastin anticoagulant therapy article blood clotting concentration (parameters) controlled study dose response heparinization human international normalized ratio normal human outpatient partial thromboplastin time prothrombin time sensitivity analysis statistical significance
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p87_Duboscq http://hdl.handle.net/20.500.12110/paper_03252957_v39_n1_p87_Duboscq
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03252957_v39_n1_p87_Duboscq
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spelling	paper:paper_03252957_v39_n1_p87_Duboscq2023-06-08T15:32:18Z Effect of sodium citrate concentration on coagulation assays Duboscq, Cristina Kordich, Lucía Clelia Activated partial thromboplastin time Prothrombin time Sodium citrate concentration citrate sodium heparin reagent thromboplastin anticoagulant therapy article blood clotting concentration (parameters) controlled study dose response heparinization human international normalized ratio normal human outpatient partial thromboplastin time prothrombin time sensitivity analysis statistical significance The aim of this study was to assess the extent of influence of citrate concentration on the results of routine coagulation assays (prothrombin time (PT) and activated partial thromboplastin time (APTT). PT was evaluated using three tromboplastins of different origin and APTT was determined by four different APTT reagents. Three methods of clot detecction were used (manual, photo-optic and electromecanic). Three groups were studied: healthy volunteers, outpatients receiving stable dosis of oral anticoagulant therapy and hospitalized patients receiving non fractionated heparin therapy. There were no statistically significant differences of TP expressed in percentaje. In patients receiving dicumarinic therapy, the INR (International Normatized Ratio) obtained with two thromboplastins of lower ISI showed a statistically significant difference between two citrate concentrations. This difference is more important when the RIN is greater than 3.5. Effects of sodium citrate concentration on APTT were satistically significant in all groups when a reagent sensitive to aid the detection of lupus anticoagulant was used. For APTT the greatest change was observed in patients receiving heparin therapy. Fil:Duboscq, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p87_Duboscq http://hdl.handle.net/20.500.12110/paper_03252957_v39_n1_p87_Duboscq
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Activated partial thromboplastin time Prothrombin time Sodium citrate concentration citrate sodium heparin reagent thromboplastin anticoagulant therapy article blood clotting concentration (parameters) controlled study dose response heparinization human international normalized ratio normal human outpatient partial thromboplastin time prothrombin time sensitivity analysis statistical significance
spellingShingle	Activated partial thromboplastin time Prothrombin time Sodium citrate concentration citrate sodium heparin reagent thromboplastin anticoagulant therapy article blood clotting concentration (parameters) controlled study dose response heparinization human international normalized ratio normal human outpatient partial thromboplastin time prothrombin time sensitivity analysis statistical significance Duboscq, Cristina Kordich, Lucía Clelia Effect of sodium citrate concentration on coagulation assays
topic_facet	Activated partial thromboplastin time Prothrombin time Sodium citrate concentration citrate sodium heparin reagent thromboplastin anticoagulant therapy article blood clotting concentration (parameters) controlled study dose response heparinization human international normalized ratio normal human outpatient partial thromboplastin time prothrombin time sensitivity analysis statistical significance
description	The aim of this study was to assess the extent of influence of citrate concentration on the results of routine coagulation assays (prothrombin time (PT) and activated partial thromboplastin time (APTT). PT was evaluated using three tromboplastins of different origin and APTT was determined by four different APTT reagents. Three methods of clot detecction were used (manual, photo-optic and electromecanic). Three groups were studied: healthy volunteers, outpatients receiving stable dosis of oral anticoagulant therapy and hospitalized patients receiving non fractionated heparin therapy. There were no statistically significant differences of TP expressed in percentaje. In patients receiving dicumarinic therapy, the INR (International Normatized Ratio) obtained with two thromboplastins of lower ISI showed a statistically significant difference between two citrate concentrations. This difference is more important when the RIN is greater than 3.5. Effects of sodium citrate concentration on APTT were satistically significant in all groups when a reagent sensitive to aid the detection of lupus anticoagulant was used. For APTT the greatest change was observed in patients receiving heparin therapy.
author	Duboscq, Cristina Kordich, Lucía Clelia
author_facet	Duboscq, Cristina Kordich, Lucía Clelia
author_sort	Duboscq, Cristina
title	Effect of sodium citrate concentration on coagulation assays
title_short	Effect of sodium citrate concentration on coagulation assays
title_full	Effect of sodium citrate concentration on coagulation assays
title_fullStr	Effect of sodium citrate concentration on coagulation assays
title_full_unstemmed	Effect of sodium citrate concentration on coagulation assays
title_sort	effect of sodium citrate concentration on coagulation assays
publishDate	2005
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n1_p87_Duboscq http://hdl.handle.net/20.500.12110/paper_03252957_v39_n1_p87_Duboscq
work_keys_str_mv	AT duboscqcristina effectofsodiumcitrateconcentrationoncoagulationassays AT kordichluciaclelia effectofsodiumcitrateconcentrationoncoagulationassays
_version_	1768545509812731904

Effect of sodium citrate concentration on coagulation assays

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